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Target
N-acylneuraminate-9-phosphatase
Ligand
BDBM50436923
Substrate
n/a
Meas. Tech.
ChEMBL_969219 (CHEMBL2404639)
IC50
11000±n/a nM
Citation
 Kim, SH; Constantine, KL; Duke, GJ; Goldfarb, V; Hunt, JT; Johnson, S; Kish, K; Klei, HE; McDonnell, PA; Metzler, WJ; Mueller, L; Poss, MA; Fairchild, CR; Bhide, RS Design, synthesis, functional and structural characterization of an inhibitor of N-acetylneuraminate-9-phosphate phosphatase: observation of extensive dynamics in an enzyme/inhibitor complex. Bioorg Med Chem Lett 23:4107-11 (2013) [PubMed]  Article
Target
Name:
N-acylneuraminate-9-phosphatase
Synonyms:
C20orf147 | HDHD4 | Haloacid dehalogenase-like hydrolase domain-containing protein 4 | NANP | NANP_HUMAN | Neu5Ac-9-Pase
Type:
PROTEIN
Mol. Mass.:
27812.32
Organism:
Homo sapiens (Human)
Description:
ChEMBL_107619
Residue:
248
Sequence:
MGLSRVRAVFFDLDNTLIDTAGASRRGMLEVIKLLQSKYHYKEEAEIICDKVQVKLSKECFHPYNTCITDLRTSHWEEAIQETKGGAANRKLAEECYFLWKSTRLQHMTLAEDVKAMLTELRKEVRLLLLTNGDRQTQREKIEACACQSYFDAVVVGGEQREEKPAPSIFYYCCNLLGVQPGDCVMVGDTLETDIQGGLNAGLKATVWINKNGIVPLKSSPVPHYMVSSVLELPALLQSIDCKVSMST
  
Inhibitor
Name:
BDBM50436923
Synonyms:
CHEMBL2402022
Type:
Small organic molecule
Emp. Form.:
C12H22NO11P
Mol. Mass.:
387.2769
SMILES:
CC(=O)N[C@@H]1[C@@H](O)C[C@](O)(O[C@H]1[C@H](O)[C@H](O)CCP(O)(O)=O)C(O)=O |r|
Structure:
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