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Target
Replication protein A 70 kDa DNA-binding subunit
Ligand
BDBM50437283
Substrate
n/a
Meas. Tech.
ChEMBL_972453 (CHEMBL2412823)
Kd
1850000±n/a nM
Citation
 Patrone, JD; Kennedy, JP; Frank, AO; Feldkamp, MD; Vangamudi, B; Pelz, NF; Rossanese, OW; Waterson, AG; Chazin, WJ; Fesik, SW Discovery of Protein-Protein Interaction Inhibitors of Replication Protein A. ACS Med Chem Lett 4:601-605 (2013) [PubMed]  Article
Target
Name:
Replication protein A 70 kDa DNA-binding subunit
Synonyms:
REPA1 | RF-A protein 1 | RFA1_HUMAN | RP-A p70 | RPA1 | RPA70 | Replication factor A protein 1 | Single-stranded DNA-binding protein
Type:
Enzyme
Mol. Mass.:
68139.43
Organism:
Homo sapiens (Human)
Description:
P27694
Residue:
616
Sequence:
MVGQLSEGAIAAIMQKGDTNIKPILQVINIRPITTGNSPPRYRLLMSDGLNTLSSFMLATQLNPLVEEEQLSSNCVCQIHRFIVNTLKDGRRVVILMELEVLKSAEAVGVKIGNPVPYNEGLGQPQVAPPAPAASPAASSRPQPQNGSSGMGSTVSKAYGASKTFGKAAGPSLSHTSGGTQSKVVPIASLTPYQSKWTICARVTNKSQIRTWSNSRGEGKLFSLELVDESGEIRATAFNEQVDKFFPLIEVNKVYYFSKGTLKIANKQFTAVKNDYEMTFNNETSVMPCEDDHHLPTVQFDFTGIDDLENKSKDSLVDIIGICKSYEDATKITVRSNNREVAKRNIYLMDTSGKVVTATLWGEDADKFDGSRQPVLAIKGARVSDFGGRSLSVLSSSTIIANPDIPEAYKLRGWFDAEGQALDGVSISDLKSGGVGGSNTNWKTLYEVKSENLGQGDKPDYFSSVATVVYLRKENCMYQACPTQDCNKKVIDQQNGLYRCEKCDTEFPNFKYRMILSVNIADFQENQWVTCFQESAEAILGQNAAYLGELKDKNEQAFEEVFQNANFRSFIFRVRVKVETYNDESRIKATVMDVKPVDYREYGRRLVMSIRRSALM
  
Inhibitor
Name:
BDBM50437283
Synonyms:
CHEMBL449442
Type:
Small organic molecule
Emp. Form.:
C7H5ClN4
Mol. Mass.:
180.594
SMILES:
Clc1ccc(cc1)-c1nnn[nH]1
Structure:
Search PDB for entries with ligand similarity: