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Target
15-hydroxyprostaglandin dehydrogenase [NAD(+)]
Ligand
BDBM50438412
Substrate
n/a
Meas. Tech.
ChEMBL_975738 (CHEMBL2415236)
IC50
132±n/a nM
Citation
 Choi, D; Piao, YL; Wu, Y; Cho, H Control of the intracellular levels of prostaglandin E2 through inhibition of the 15-hydroxyprostaglandin dehydrogenase for wound healing. Bioorg Med Chem 21:4477-84 (2013) [PubMed]  Article
Target
Name:
15-hydroxyprostaglandin dehydrogenase [NAD(+)]
Synonyms:
15-PGDH | 15-hydroxyprostaglandin dehydrogenase [NAD+] | HPGD | PGDH1 | PGDH_HUMAN | Prostaglandin dehydrogenase 1 (15-PGDH) | SDR36C1
Type:
Enzyme
Mol. Mass.:
28974.46
Organism:
Homo sapiens (Human)
Description:
P15428
Residue:
266
Sequence:
MHVNGKVALVTGAAQGIGRAFAEALLLKGAKVALVDWNLEAGVQCKAALDEQFEPQKTLFIQCDVADQQQLRDTFRKVVDHFGRLDILVNNAGVNNEKNWEKTLQINLVSVISGTYLGLDYMSKQNGGEGGIIINMSSLAGLMPVAQQPVYCASKHGIVGFTRSAALAANLMNSGVRLNAICPGFVNTAILESIEKEENMGQYIEYKDHIKDMIKYYGILDPPLIANGLITLIEDDALNGAIMKITTSKGIHFQDYDTTPFQAKTQ
  
Inhibitor
Name:
BDBM50438412
Synonyms:
CHEMBL2414151
Type:
Small organic molecule
Emp. Form.:
C15H14ClNO3S
Mol. Mass.:
323.795
SMILES:
CC(Oc1ccc(C=C2SC(O)=NC2=O)cc1Cl)C1CC1 |w:7.6,c:11|
Structure:
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