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Target
15-hydroxyprostaglandin dehydrogenase [NAD(+)]
Ligand
BDBM50438416
Substrate
n/a
Meas. Tech.
ChEMBL_975738 (CHEMBL2415236)
IC50
20±n/a nM
Citation
 Choi, D; Piao, YL; Wu, Y; Cho, H Control of the intracellular levels of prostaglandin E2 through inhibition of the 15-hydroxyprostaglandin dehydrogenase for wound healing. Bioorg Med Chem 21:4477-84 (2013) [PubMed]  Article
Target
Name:
15-hydroxyprostaglandin dehydrogenase [NAD(+)]
Synonyms:
15-PGDH | 15-hydroxyprostaglandin dehydrogenase [NAD+] | HPGD | PGDH1 | PGDH_HUMAN | Prostaglandin dehydrogenase 1 (15-PGDH) | SDR36C1
Type:
Enzyme
Mol. Mass.:
28974.46
Organism:
Homo sapiens (Human)
Description:
P15428
Residue:
266
Sequence:
MHVNGKVALVTGAAQGIGRAFAEALLLKGAKVALVDWNLEAGVQCKAALDEQFEPQKTLFIQCDVADQQQLRDTFRKVVDHFGRLDILVNNAGVNNEKNWEKTLQINLVSVISGTYLGLDYMSKQNGGEGGIIINMSSLAGLMPVAQQPVYCASKHGIVGFTRSAALAANLMNSGVRLNAICPGFVNTAILESIEKEENMGQYIEYKDHIKDMIKYYGILDPPLIANGLITLIEDDALNGAIMKITTSKGIHFQDYDTTPFQAKTQ
  
Inhibitor
Name:
BDBM50438416
Synonyms:
CHEMBL2414147
Type:
Small organic molecule
Emp. Form.:
C18H20ClNO4S
Mol. Mass.:
381.874
SMILES:
OC1=NC(=O)C(S1)=Cc1ccc(OCCOC2CCCCC2)c(Cl)c1 |w:7.8,t:1|
Structure:
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