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Target
Poly [ADP-ribose] polymerase 2
Ligand
BDBM50011421
Substrate
n/a
Meas. Tech.
ChEMBL_984399 (CHEMBL2433123)
IC50
8318±n/a nM
Citation
 Narwal, M; Koivunen, J; Haikarainen, T; Obaji, E; Legala, OE; Venkannagari, H; Joensuu, P; Pihlajaniemi, T; Lehtiö, L Discovery of tankyrase inhibiting flavones with increased potency and isoenzyme selectivity. J Med Chem 56:7880-9 (2013) [PubMed]  Article
Target
Name:
Poly [ADP-ribose] polymerase 2
Synonyms:
(ARTD2 or PARP2) | ADPRT2 | ADPRTL2 | PARP2 | PARP2_HUMAN | Poly [ADP-ribose] polymerase 2 (PARP-2) | Poly [ADP-ribose] polymerase 2 (PARP2)
Type:
Enzyme
Mol. Mass.:
66225.70
Organism:
Homo sapiens (Human)
Description:
Q9UGN5
Residue:
583
Sequence:
MAARRRRSTGGGRARALNESKRVNNGNTAPEDSSPAKKTRRCQRQESKKMPVAGGKANKDRTEDKQDGMPGRSWASKRVSESVKALLLKGKAPVDPECTAKVGKAHVYCEGNDVYDVMLNQTNLQFNNNKYYLIQLLEDDAQRNFSVWMRWGRVGKMGQHSLVACSGNLNKAKEIFQKKFLDKTKNNWEDREKFEKVPGKYDMLQMDYATNTQDEEETKKEESLKSPLKPESQLDLRVQELIKLICNVQAMEEMMMEMKYNTKKAPLGKLTVAQIKAGYQSLKKIEDCIRAGQHGRALMEACNEFYTRIPHDFGLRTPPLIRTQKELSEKIQLLEALGDIEIAIKLVKTELQSPEHPLDQHYRNLHCALRPLDHESYEFKVISQYLQSTHAPTHSDYTMTLLDLFEVEKDGEKEAFREDLHNRMLLWHGSRMSNWVGILSHGLRIAPPEAPITGYMFGKGIYFADMSSKSANYCFASRLKNTGLLLLSEVALGQCNELLEANPKAEGLLQGKHSTKGLGKMAPSSAHFVTLNGSTVPLGPASDTGILNPDGYTLNYNEYIVYNPNQVRMRYLLKVQFNFLQLW
  
Inhibitor
Name:
BDBM50011421
Synonyms:
2-(4-Nitro-phenyl)-chromen-4-one | CHEMBL64780
Type:
Small organic molecule
Emp. Form.:
C15H9NO4
Mol. Mass.:
267.2363
SMILES:
[O-][N+](=O)c1ccc(cc1)-c1cc(=O)c2ccccc2o1
Structure:
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