Reaction Details  Report a problem with these data
Target
Prostaglandin E2 receptor EP2 subtype
Ligand
BDBM50442299
Substrate
n/a
Meas. Tech.
ChEMBL_993226 (CHEMBL2447516)
IC50
>10000±n/a nM
Citation
 Sandham, DA; Arnold, N; Aschauer, H; Bala, K; Barker, L; Brown, L; Brown, Z; Budd, D; Cox, B; Docx, C; Dubois, G; Duggan, N; England, K; Everatt, B; Furegati, M; Hall, E; Kalthoff, F; King, A; Leblanc, CJ; Manini, J; Meingassner, J; Profit, R; Schmidt, A; Simmons, J; Sohal, B; Stringer, R; Thomas, M; Turner, KL; Walker, C; Watson, SJ; Westwick, J; Willis, J; Williams, G; Wilson, C Discovery and characterization of NVP-QAV680, a potent and selective CRTh2 receptor antagonist suitable for clinical testing in allergic diseases. Bioorg Med Chem 21:6582-91 (2013) [PubMed]  Article
Target
Name:
Prostaglandin E2 receptor EP2 subtype
Synonyms:
PE2R2_HUMAN | PGE receptor EP2 subtype | PTGER2 | Prostaglandin E2 | Prostaglandin E2 receptor | Prostaglandin E2 receptor EP4 subtype | Prostanoid EP2 Receptor
Type:
Enzyme
Mol. Mass.:
39775.71
Organism:
Homo sapiens (Human)
Description:
P43116
Residue:
358
Sequence:
MGNASNDSQSEDCETRQWLPPGESPAISSVMFSAGVLGNLIALALLARRWRGDVGCSAGRRSSLSLFHVLVTELVFTDLLGTCLISPVVLASYARNQTLVALAPESRACTYFAFAMTFFSLATMLMLFAMALERYLSIGHPYFYQRRVSRSGGLAVLPVIYAVSLLFCSLPLLDYGQYVQYCPGTWCFIRHGRTAYLQLYATLLLLLIVSVLACNFSVILNLIRMHRRSRRSRCGPSLGSGRGGPGARRRGERVSMAEETDHLILLAIMTITFAVCSLPFTIFAYMNETSSRKEKWDLQALRFLSINSIIDPWVFAILRPPVLRLMRSVLCCRISLRTQDATQTSCSTQSDASKQADL
  
Inhibitor
Name:
BDBM50442299
Synonyms:
CHEMBL2442750
Type:
Small organic molecule
Emp. Form.:
C18H18N2O4S
Mol. Mass.:
358.412
SMILES:
Cc1c(CC(O)=O)c2cccnc2n1Cc1ccc(cc1)S(C)(=O)=O
Structure:
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