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Target
Cytochrome P450 2D6
Ligand
BDBM50446661
Substrate
n/a
Meas. Tech.
ChEMBL_1290450 (CHEMBL3119561)
IC50
>30000±n/a nM
Citation
 Ma, Y; Lahue, BR; Shipps, GW; Brookes, J; Wang, Y Substituted piperidines as HDM2 inhibitors. Bioorg Med Chem Lett 24:1026-30 (2014) [PubMed]  Article
Target
Name:
Cytochrome P450 2D6
Synonyms:
CP2D6_HUMAN | CYP2D6 | CYP2DL1 | CYPIID6 | Cytochrome P450 2D6 (CYP2D6) | Debrisoquine 4-hydroxylase | P450-DB1
Type:
Protein
Mol. Mass.:
55774.82
Organism:
Homo sapiens (Human)
Description:
P10635
Residue:
497
Sequence:
MGLEALVPLAVIVAIFLLLVDLMHRRQRWAARYPPGPLPLPGLGNLLHVDFQNTPYCFDQLRRRFGDVFSLQLAWTPVVVLNGLAAVREALVTHGEDTADRPPVPITQILGFGPRSQGVFLARYGPAWREQRRFSVSTLRNLGLGKKSLEQWVTEEAACLCAAFANHSGRPFRPNGLLDKAVSNVIASLTCGRRFEYDDPRFLRLLDLAQEGLKEESGFLREVLNAVPVLLHIPALAGKVLRFQKAFLTQLDELLTEHRMTWDPAQPPRDLTEAFLAEMEKAKGNPESSFNDENLRIVVADLFSAGMVTTSTTLAWGLLLMILHPDVQRRVQQEIDDVIGQVRRPEMGDQAHMPYTTAVIHEVQRFGDIVPLGVTHMTSRDIEVQGFRIPKGTTLITNLSSVLKDEAVWEKPFRFHPEHFLDAQGHFVKPEAFLPFSAGRRACLGEPLARMELFLFFTSLLQHFSFSVPTGQPRPSHHGVFAFLVSPSPYELCAVPR
  
Inhibitor
Name:
BDBM50446661
Synonyms:
CHEMBL3112778
Type:
Small organic molecule
Emp. Form.:
C33H34F6N4O5
Mol. Mass.:
680.6373
SMILES:
COCCOc1ccccc1N1CCN(CC1)C(=O)C1(CCCN(C1)C(=O)c1cnccc1C(F)(F)F)Oc1ccc(cc1)C(F)(F)F
Structure:
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