Target

Ligand

Substrate

Meas. Tech.

ChEMBL_1291282 (CHEMBL3117272)

Citation

 Kale, RR; Kale, MG; Waterson, D; Raichurkar, A; Hameed, SP; Manjunatha, MR; Kishore Reddy, BK; Malolanarasimhan, K; Shinde, V; Koushik, K; Jena, LK; Menasinakai, S; Humnabadkar, V; Madhavapeddi, P; Basavarajappa, H; Sharma, S; Nandishaiah, R; Mahesh Kumar, KN; Ganguly, S; Ahuja, V; Gaonkar, S; Naveen Kumar, CN; Ogg, D; Boriack-Sjodin, PA; Sambandamurthy, VK; de Sousa, SM; Ghorpade, SR Thiazolopyridone ureas as DNA gyrase B inhibitors: optimization of antitubercular activity and efficacy. Bioorg Med Chem Lett 24:870-9 (2014) [PubMed]  Article

More Info.:

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Name:

DNA gyrase subunit B

Synonyms:

GYRB_MYCSM | gyrB

Type:

PROTEIN

Mol. Mass.:

74505.25

Organism:

Mycobacterium smegmatis

Description:

ChEMBL_107961

Residue:

675

Sequence:

MAAQKNNAPKEYGADSITILEGLEAVRKRPGMYIGSTGERGLHHLIWEVVDNAVDEAMAGFATRVDVKIHADGSVEVRDDGRGIPVEMHATGMPTIDVVMTQLHAGGKFDGETYAVSGGLHGVGVSVVNALSTRLEATVLRDGYEWFQYYDRSVPGKLKQGGETKETGTTIRFWADPEIFETTDYNFETVARRLQEMAFLNKGLTIELTDERVTAEEVVDDVVKDTAEAPKTADEKAAEATGPSKVKHRVFHYPGGLVDYVKHINRTKTPIQQSIIDFDGKGPGHEVEIAMQWNAGYSESVHTFANTINTHEGGTHEEGFRAALTSVVNRYAKDKKLLKDKDPNLTGDDIREGLAAVISVKVAEPQFEGQTKTKLGNTEVKSFVQKICNEQLQHWFEANPAEAKTVVNKAVSSAQARIAARKARELVRRKSATDIGGLPGKLADCRSTDPSKSELYVVEGDSAGGSAKSGRDSMFQAILPLRGKIINVEKARIDRVLKNTEVQSIITALGTGIHDEFDISKLRYHKIVLMADADVDGQHISTLLLTLLFRFMKPLVENGHIFLAQPPLYKLKWQRSEPEFAYSDRERDGLLEAGRAAGKKINVDDGIQRYKGLGEMDAKELWETTMDPSVRVLRQVTLDDAAAADELFSILMGEDVEARRSFITRNAKDVRFLDV

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Name:

BDBM50447299

Synonyms:

CHEMBL3114208

Type:

Small organic molecule

Emp. Form.:

C21H27N5O4S

Mol. Mass.:

445.535

SMILES:

CCNC(=O)Nc1nc2cc(-c3cc(C)n(CCOC)c(=O)c3)c(=O)n(C(C)C)c2s1

Structure:

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