Reaction Details  Report a problem with these data
Target
Histamine H1 receptor
Ligand
BDBM50448210
Substrate
n/a
Meas. Tech.
ChEMBL_1293155 (CHEMBL3123285)
Ki
14±n/a nM
Citation
 Chen, Y; Lan, Y; Wang, S; Zhang, H; Xu, X; Liu, X; Yu, M; Liu, BF; Zhang, G Synthesis and evaluation of new coumarin derivatives as potential atypical antipsychotics. Eur J Med Chem 74:427-39 (2014) [PubMed]  Article
Target
Name:
Histamine H1 receptor
Synonyms:
HISTAMINE H1 | HRH1 | HRH1_CAVPO
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
55641.53
Organism:
Cavia porcellus (domestic guinea pig)
Description:
Guinea pig cerebellum was used in binding assay.
Residue:
488
Sequence:
MSFLPGMTPVTLSNFSWALEDRMLEGNSTTTPTRQLMPLVVVLSSVSLVTVALNLLVLYAVRSERKLHTVGNLYIVSLSVADLIVGAVVMPMSILYLHRSAWILGRPLCLFWLSMDYVASTASIFSVFILCIDRYRSVQQPLRYLRYRTKTRASATILGAWLLSFLWVIPILGWHHFMAPTSEPREKKCETDFYDVTWFKVMTAIINFYLPTLLMLWFYIRIYKAVRRHCQHRQLINSSLPSFSEMKLKLENAKVDTRRMGKESPWEDPKRCSKDASGVHTPMPSSQHLVDMPCAAVLSEDEGGEVGTRQMPMLAVGDGRCCEALNHMHSQLELSGQSRATHSISARPEEWTVVDGQSFPITDSDTSTEAAPMGGQPRSGSNSGLDYIKFTWRRLRSHSRQYTSGLHLNRERKAAKQLGCIMAAFILCWIPYFVFFMVIAFCKSCSNEPVHMFTIWLGYLNSTLNPLIYPLCNENFRKTFKRILRIPP
  
Inhibitor
Name:
BDBM50448210
Synonyms:
CHEMBL3120697 | US9018213, 15
Type:
Small organic molecule
Emp. Form.:
C28H28ClFN2O4
Mol. Mass.:
510.984
SMILES:
Fc1ccc2c(noc2c1)C1CCN(CCCCOc2ccc3c4CCCc4c(=O)oc3c2Cl)CC1
Structure:
Search PDB for entries with ligand similarity: