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Target
Histamine H1 receptor
Ligand
BDBM50448211
Substrate
n/a
Meas. Tech.
ChEMBL_1293155 (CHEMBL3123285)
Ki
1825±n/a nM
Citation
 Chen, Y; Lan, Y; Wang, S; Zhang, H; Xu, X; Liu, X; Yu, M; Liu, BF; Zhang, G Synthesis and evaluation of new coumarin derivatives as potential atypical antipsychotics. Eur J Med Chem 74:427-39 (2014) [PubMed]  Article
Target
Name:
Histamine H1 receptor
Synonyms:
HISTAMINE H1 | HRH1 | HRH1_CAVPO
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
55641.53
Organism:
Cavia porcellus (domestic guinea pig)
Description:
Guinea pig cerebellum was used in binding assay.
Residue:
488
Sequence:
MSFLPGMTPVTLSNFSWALEDRMLEGNSTTTPTRQLMPLVVVLSSVSLVTVALNLLVLYAVRSERKLHTVGNLYIVSLSVADLIVGAVVMPMSILYLHRSAWILGRPLCLFWLSMDYVASTASIFSVFILCIDRYRSVQQPLRYLRYRTKTRASATILGAWLLSFLWVIPILGWHHFMAPTSEPREKKCETDFYDVTWFKVMTAIINFYLPTLLMLWFYIRIYKAVRRHCQHRQLINSSLPSFSEMKLKLENAKVDTRRMGKESPWEDPKRCSKDASGVHTPMPSSQHLVDMPCAAVLSEDEGGEVGTRQMPMLAVGDGRCCEALNHMHSQLELSGQSRATHSISARPEEWTVVDGQSFPITDSDTSTEAAPMGGQPRSGSNSGLDYIKFTWRRLRSHSRQYTSGLHLNRERKAAKQLGCIMAAFILCWIPYFVFFMVIAFCKSCSNEPVHMFTIWLGYLNSTLNPLIYPLCNENFRKTFKRILRIPP
  
Inhibitor
Name:
BDBM50448211
Synonyms:
CHEMBL3120696
Type:
Small organic molecule
Emp. Form.:
C29H31FN2O4
Mol. Mass.:
490.5658
SMILES:
Cc1c(OCCCCN2CCC(CC2)c2noc3cc(F)ccc23)ccc2c3CCCc3c(=O)oc12
Structure:
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