Reaction Details  Report a problem with these data
Target
Fructose-1,6-bisphosphatase 1
Ligand
BDBM50449193
Substrate
n/a
Meas. Tech.
ChEMBL_1297731 (CHEMBL3131191)
IC50
7400±n/a nM
Citation
 Bie, J; Liu, S; Zhou, J; Xu, B; Shen, Z Design, synthesis and biological evaluation of 7-nitro-1H-indole-2-carboxylic acid derivatives as allosteric inhibitors of fructose-1,6-bisphosphatase. Bioorg Med Chem 22:1850-62 (2014) [PubMed]  Article
Target
Name:
Fructose-1,6-bisphosphatase 1
Synonyms:
D-fructose-1,6-bisphosphate 1-phosphohydrolase 1 | F16P1_HUMAN | FBP | FBP1 | FBPase 1 | Fructose-1,6-bisphosphatase | Fructose-1,6-bisphosphatase 1 | Fructose-1,6-bisphosphatase 1 (FBPase)
Type:
Protein
Mol. Mass.:
36843.58
Organism:
Homo sapiens (Human)
Description:
Liver FBPase (P09467)
Residue:
338
Sequence:
MADQAPFDTDVNTLTRFVMEEGRKARGTGELTQLLNSLCTAVKAISSAVRKAGIAHLYGIAGSTNVTGDQVKKLDVLSNDLVMNMLKSSFATCVLVSEEDKHAIIVEPEKRGKYVVCFDPLDGSSNIDCLVSVGTIFGIYRKKSTDEPSEKDALQPGRNLVAAGYALYGSATMLVLAMDCGVNCFMLDPAIGEFILVDKDVKIKKKGKIYSLNEGYARDFDPAVTEYIQRKKFPPDNSAPYGARYVGSMVADVHRTLVYGGIFLYPANKKSPNGKLRLLYECNPMAYVMEKAGGMATTGKEAVLDVIPTDIHQRAPVILGSPDDVLEFLKVYEKHSAQ
  
Inhibitor
Name:
BDBM50449193
Synonyms:
CHEMBL3127754
Type:
Small organic molecule
Emp. Form.:
C17H13N3O5
Mol. Mass.:
339.3022
SMILES:
CC(=O)Nc1cccc(c1)-c1c([nH]c2c(cccc12)[N+]([O-])=O)C(O)=O
Structure:
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