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Target
Dual specificity protein kinase CLK1
Ligand
BDBM7401
Substrate
n/a
Meas. Tech.
ChEMBL_1297733 (CHEMBL3131193)
IC50
2100±n/a nM
Citation
 Waiker, DK; Karthikeyan, C; Poongavanam, V; Kongsted, J; Lozach, O; Meijer, L; Trivedi, P Synthesis, biological evaluation and molecular modelling studies of 4-anilinoquinazoline derivatives as protein kinase inhibitors. Bioorg Med Chem 22:1909-15 (2014) [PubMed]  Article
Target
Name:
Dual specificity protein kinase CLK1
Synonyms:
CDC-like kinase 1 | CDC-like kinase 1 (CLK1) | CDC2-like kinase 1 (CLK1) | CLK | CLK1 | CLK1_HUMAN | Dual specificity protein kinase CLK1 | Dual specificity protein kinase CLK1/CLK4 | Dual specificty protein kinase CLK1
Type:
Protein
Mol. Mass.:
57322.21
Organism:
Homo sapiens (Human)
Description:
P49759
Residue:
484
Sequence:
MRHSKRTYCPDWDDKDWDYGKWRSSSSHKRRKRSHSSAQENKRCKYNHSKMCDSHYLESRSINEKDYHSRRYIDEYRNDYTQGCEPGHRQRDHESRYQNHSSKSSGRSGRSSYKSKHRIHHSTSHRRSHGKSHRRKRTRSVEDDEEGHLICQSGDVLSARYEIVDTLGEGAFGKVVECIDHKAGGRHVAVKIVKNVDRYCEAARSEIQVLEHLNTTDPNSTFRCVQMLEWFEHHGHICIVFELLGLSTYDFIKENGFLPFRLDHIRKMAYQICKSVNFLHSNKLTHTDLKPENILFVQSDYTEAYNPKIKRDERTLINPDIKVVDFGSATYDDEHHSTLVSTRHYRAPEVILALGWSQPCDVWSIGCILIEYYLGFTVFPTHDSKEHLAMMERILGPLPKHMIQKTRKRKYFHHDRLDWDEHSSAGRYVSRRCKPLKEFMLSQDVEHERLFDLIQKMLEYDPAKRITLREALKHPFFDLLKKSI
  
Inhibitor
Name:
BDBM7401
Synonyms:
(2 Z,3 E)-6-Bromoindirubin-3 -oxime | (3E)-6-bromo-3-[3-(hydroxyamino)indol-2-ylidene]oxindole | 6-bromo-3-[(2Z,3E)-3-(hydroxyimino)-2,3-dihydro-1H-indol-2-ylidene]-2,3-dihydro-1H-indol-2-one | 6-bromoindirubin-3 -oxime | 6BIO | CHEMBL409450 | indirubin deriv. 7a
Type:
Small organic molecule
Emp. Form.:
C16H10BrN3O2
Mol. Mass.:
356.174
SMILES:
Brc1ccc2C(C(=O)Nc2c1)c1[nH]c2ccccc2c1N=O
Structure:
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