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Target
Dual specificity protein kinase CLK1
Ligand
BDBM50291090
Substrate
n/a
Meas. Tech.
ChEMBL_1297733 (CHEMBL3131193)
IC50
>10000±n/a nM
Citation
 Waiker, DK; Karthikeyan, C; Poongavanam, V; Kongsted, J; Lozach, O; Meijer, L; Trivedi, P Synthesis, biological evaluation and molecular modelling studies of 4-anilinoquinazoline derivatives as protein kinase inhibitors. Bioorg Med Chem 22:1909-15 (2014) [PubMed]  Article
Target
Name:
Dual specificity protein kinase CLK1
Synonyms:
CDC-like kinase 1 | CDC-like kinase 1 (CLK1) | CDC2-like kinase 1 (CLK1) | CLK | CLK1 | CLK1_HUMAN | Dual specificity protein kinase CLK1 | Dual specificity protein kinase CLK1/CLK4 | Dual specificty protein kinase CLK1
Type:
Protein
Mol. Mass.:
57322.21
Organism:
Homo sapiens (Human)
Description:
P49759
Residue:
484
Sequence:
MRHSKRTYCPDWDDKDWDYGKWRSSSSHKRRKRSHSSAQENKRCKYNHSKMCDSHYLESRSINEKDYHSRRYIDEYRNDYTQGCEPGHRQRDHESRYQNHSSKSSGRSGRSSYKSKHRIHHSTSHRRSHGKSHRRKRTRSVEDDEEGHLICQSGDVLSARYEIVDTLGEGAFGKVVECIDHKAGGRHVAVKIVKNVDRYCEAARSEIQVLEHLNTTDPNSTFRCVQMLEWFEHHGHICIVFELLGLSTYDFIKENGFLPFRLDHIRKMAYQICKSVNFLHSNKLTHTDLKPENILFVQSDYTEAYNPKIKRDERTLINPDIKVVDFGSATYDDEHHSTLVSTRHYRAPEVILALGWSQPCDVWSIGCILIEYYLGFTVFPTHDSKEHLAMMERILGPLPKHMIQKTRKRKYFHHDRLDWDEHSSAGRYVSRRCKPLKEFMLSQDVEHERLFDLIQKMLEYDPAKRITLREALKHPFFDLLKKSI
  
Inhibitor
Name:
BDBM50291090
Synonyms:
(6,7-Dimethoxy-quinazolin-4-yl)-p-tolyl-amine; hydrochloride | CHEMBL1191611 | CHEMBL542733 | US10548897, Compound 3
Type:
Small organic molecule
Emp. Form.:
C17H17N3O3
Mol. Mass.:
311.3352
SMILES:
COc1ccc(Nc2ncnc3cc(OC)c(OC)cc23)cc1
Structure:
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