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Target
Neutrophil elastase
Ligand
BDBM50449286
Substrate
n/a
Meas. Tech.
ChEMBL_1295176 (CHEMBL3128722)
IC50
4220±n/a nM
Citation
 Muscia, GC; Hautmann, S; Buldain, GY; Asís, SE; Gütschow, M Synthesis and evaluation of 2-(1H-indol-3-yl)-4-phenylquinolines as inhibitors of cholesterol esterase. Bioorg Med Chem Lett 24:1545-9 (2014) [PubMed]  Article
Target
Name:
Neutrophil elastase
Synonyms:
Bone marrow serine protease | Chymotrypsin | Coagulation factor X | ELA2 | ELANE | ELNE_HUMAN | Elastase | Elastase-2 | HLE | Human leukocyte elastase | Leukocyte elastase | Leukocyte elastase (HLE) | Medullasin | Neutrophil elastase | Neutrophil elastase (HNE) | Neutrophil elastase (NE) | PMN elastase | Thrombin | Trypsin
Type:
Enzyme
Mol. Mass.:
28532.38
Organism:
Homo sapiens (Human)
Description:
P08246
Residue:
267
Sequence:
MTLGRRLACLFLACVLPALLLGGTALASEIVGGRRARPHAWPFMVSLQLRGGHFCGATLIAPNFVMSAAHCVANVNVRAVRVVLGAHNLSRREPTRQVFAVQRIFENGYDPVNLLNDIVILQLNGSATINANVQVAQLPAQGRRLGNGVQCLAMGWGLLGRNRGIASVLQELNVTVVTSLCRRSNVCTLVRGRQAGVCFGDSGSPLVCNGLIHGIASFVRGGCASGLYPDAFAPVAQFVNWIDSIIQRSEDNPCPHPRDPDPASRTH
  
Inhibitor
Name:
BDBM50449286
Synonyms:
CHEMBL3125346
Type:
Small organic molecule
Emp. Form.:
C23H15ClN2
Mol. Mass.:
354.832
SMILES:
Clc1ccc2nc(cc(-c3ccccc3)c2c1)-c1c[nH]c2ccccc12
Structure:
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