Reaction Details  Report a problem with these data
Target
Hexokinase-4
Ligand
BDBM50165031
Substrate
n/a
Meas. Tech.
ChEMBL_1297748 (CHEMBL3131380)
EC50
3100±n/a nM
Citation
 Li, Y; Tian, K; Qin, A; Zhang, L; Huo, L; Lei, L; Shen, Z; Song, H; Feng, Z Discovery of novel urea derivatives as dual-target hypoglycemic agents that activate glucokinase and PPAR¿. Eur J Med Chem 76:182-92 (2014) [PubMed]  Article
Target
Name:
Hexokinase-4
Synonyms:
GCK | Glucokinase (GCK) | Glucokinase (GK) | Glucokinase/Glucokinase regulatory protein | HK IV | HK4 | HXK4_HUMAN | Hexokinase-4 | Hexokinase-D
Type:
Enzyme
Mol. Mass.:
52175.81
Organism:
Homo sapiens (Human)
Description:
P35557
Residue:
465
Sequence:
MLDDRARMEAAKKEKVEQILAEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPTYVRSTPEGSEVGDFLSLDLGGTNFRVMLVKVGEGEEGQWSVKTKHQMYSIPEDAMTGTAEMLFDYISECISDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDHQCEVGMIVGTGCNACYMEEMQNVELVEGDEGRMCVNTEWGAFGDSGELDEFLLEYDRLVDESSANPGQQLYEKLIGGKYMGELVRLVLLRLVDENLLFHGEASEQLRTRGAFETRFVSQVESDTGDRKQIYNILSTLGLRPSTTDCDIVRRACESVSTRAAHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFKERFHASVRRLTPSCEITFIESEEGSGRGAALVSAVACKKACMLGQ
  
Inhibitor
Name:
BDBM50165031
Synonyms:
6-({3-isopropoxy-5-[2-(3-thienyl)ethoxy]benzoyl}amino)nicotinic acid | 6-[3-Isopropoxy-5-(2-thiophen-3-yl-ethoxy)-benzoylamino]-nicotinic acid | CHEMBL373339
Type:
Small organic molecule
Emp. Form.:
C22H22N2O5S
Mol. Mass.:
426.485
SMILES:
CC(C)Oc1cc(OCCc2ccsc2)cc(c1)C(=O)Nc1ccc(cn1)C(O)=O
Structure:
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