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Target
Carbonic anhydrase 1
Ligand
BDBM10874
Substrate
n/a
Meas. Tech.
ChEMBL_956004 (CHEMBL2380061)
Ki
21000±n/a nM
Citation
 Vullo, D; Luca, VD; Scozzafava, A; Carginale, V; Rossi, M; Supuran, CT; Capasso, C The alpha-carbonic anhydrase from the thermophilic bacterium Sulfurihydrogenibium yellowstonense YO3AOP1 is highly susceptible to inhibition by sulfonamides. Bioorg Med Chem 21:1534-8 (2013) [PubMed]  Article
Target
Name:
Carbonic anhydrase 1
Synonyms:
CA-I | CA1 | CAB | CAH1_HUMAN | Carbonate dehydratase I | Carbonic anhydrase | Carbonic anhydrase 1 (CA I) | Carbonic anhydrase 1 (CA-I) | Carbonic anhydrase 1 (Recombinant CA I) | Carbonic anhydrase 2 (CA II) | Carbonic anhydrase B | Carbonic anhydrase I | Carbonic anhydrase I (CA I) | Carbonic anhydrase I (CA-I) | Carbonic anhydrase I (CAI) | Carbonic anhydrase I (hCA I) | Carbonic anhydrase isoenzyme I (hCA I) | hCA
Type:
Enzyme
Mol. Mass.:
28873.37
Organism:
Homo sapiens (Human)
Description:
P00915
Residue:
261
Sequence:
MASPDWGYDDKNGPEQWSKLYPIANGNNQSPVDIKTSETKHDTSLKPISVSYNPATAKEIINVGHSFHVNFEDNDNRSVLKGGPFSDSYRLFQFHFHWGSTNEHGSEHTVDGVKYSAELHVAHWNSAKYSSLAEAASKADGLAVIGVLMKVGEANPKLQKVLDALQAIKTKGKRAPFTNFDPSTLLPSSLDFWTYPGSLTHPPLYESVTWIICKESISVSSEQLAQFRSLLSNVEGDNAVPMQHNNRPTQPLKGRTVRASF
  
Inhibitor
Name:
BDBM10874
Synonyms:
6-hydroxy-1,3-benzothiazole-2-sulfonamide | CHEMBL6685 | aromatic/heteroaromatic sulfonamide 19
Type:
Small organic molecule
Emp. Form.:
C7H6N2O3S2
Mol. Mass.:
230.264
SMILES:
NS(=O)(=O)c1nc2ccc(O)cc2s1
Structure:
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