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Target
E3 ubiquitin-protein ligase Mdm2
Ligand
BDBM50001928
Substrate
n/a
Meas. Tech.
ChEMBL_1338947 (CHEMBL3240507)
IC50
5600±n/a nM
Citation
 Pan, W; Lahue, BR; Ma, Y; Nair, LG; Shipps, GW; Wang, Y; Doll, R; Bogen, SL Core modification of substituted piperidines as novel inhibitors of HDM2-p53 protein-protein interaction. Bioorg Med Chem Lett 24:1983-6 (2014) [PubMed]  Article
Target
Name:
E3 ubiquitin-protein ligase Mdm2
Synonyms:
Double minute 2 protein | Double minute 2 protein (HDM2) | E3 ubiquitin-protein ligase Mdm2 (p53-binding protein Mdm2) | Hdm2 | Human Double Minute 2 (HDM2) | MDM2 | MDM2-MDMX | MDM2_HUMAN | p53-Binding Protein MDM2 | p53-binding protein
Type:
Oncoprotein
Mol. Mass.:
55196.54
Organism:
Homo sapiens (Human)
Description:
Q00987
Residue:
491
Sequence:
MCNTNMSVPTDGAVTTSQIPASEQETLVRPKPLLLKLLKSVGAQKDTYTMKEVLFYLGQYIMTKRLYDEKQQHIVYCSNDLLGDLFGVPSFSVKEHRKIYTMIYRNLVVVNQQESSDSGTSVSENRCHLEGGSDQKDLVQELQEEKPSSSHLVSRPSTSSRRRAISETEENSDELSGERQRKRHKSDSISLSFDESLALCVIREICCERSSSSESTGTPSNPDLDAGVSEHSGDWLDQDSVSDQFSVEFEVESLDSEDYSLSEEGQELSDEDDEVYQVTVYQAGESDTDSFEEDPEISLADYWKCTSCNEMNPPLPSHCNRCWALRENWLPEDKGKDKGEISEKAKLENSTQAEEGFDVPDCKKTIVNDSRESCVEENDDKITQASQSQESEDYSQPSTSSSIIYSSQEDVKEFEREETQDKEESVESSLPLNAIEPCVICQGRPKNGCIVHGKTGHLMACFTCAKKLKKRNKPCPVCRQPIQMIVLTYFP
  
Inhibitor
Name:
BDBM50001928
Synonyms:
CHEMBL3233595
Type:
Small organic molecule
Emp. Form.:
C32H30F6N4O4
Mol. Mass.:
648.5954
SMILES:
[H][C@@]12C[C@]1([H])N(C[C@](C2)(Oc1ccc(cc1)C(F)(F)F)C(=O)N1CCN(CC1)c1ccccc1OC)C(=O)c1cnccc1C(F)(F)F |r|
Structure:
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