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Target
D(3) dopamine receptor
Ligand
BDBM50003064
Substrate
n/a
Meas. Tech.
ChEMBL_1335161 (CHEMBL3239710)
Ki
1900±n/a nM
Citation
 Xiao, J; Free, RB; Barnaeva, E; Conroy, JL; Doyle, T; Miller, B; Bryant-Genevier, M; Taylor, MK; Hu, X; Dulcey, AE; Southall, N; Ferrer, M; Titus, S; Zheng, W; Sibley, DR; Marugan, JJ Discovery, optimization, and characterization of novel D2 dopamine receptor selective antagonists. J Med Chem 57:3450-63 (2014) [PubMed]  Article
Target
Name:
D(3) dopamine receptor
Synonyms:
DOPAMINE D3 | DRD3 | DRD3_HUMAN | Dopamine D3 receptor | Dopamine D3 receptor (D3) | Dopamine D3 receptor (D3R) | Dopamine receptor | Dopamine receptor (D3) | Dopamine receptor D3
Type:
n/a
Mol. Mass.:
44243.43
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
400
Sequence:
MASLSQLSSHLNYTCGAENSTGASQARPHAYYALSYCALILAIVFGNGLVCMAVLKERALQTTTNYLVVSLAVADLLVATLVMPWVVYLEVTGGVWNFSRICCDVFVTLDVMMCTASILNLCAISIDRYTAVVMPVHYQHGTGQSSCRRVALMITAVWVLAFAVSCPLLFGFNTTGDPTVCSISNPDFVIYSSVVSFYLPFGVTVLVYARIYVVLKQRRRKRILTRQNSQCNSVRPGFPQQTLSPDPAHLELKRYYSICQDTALGGPGFQERGGELKREEKTRNSLSPTIAPKLSLEVRKLSNGRLSTSLKLGPLQPRGVPLREKKATQMVAIVLGAFIVCWLPFFLTHVLNTHCQTCHVSPELYSATTWLGYVNSALNPVIYTTFNIEFRKAFLKILSC
  
Inhibitor
Name:
BDBM50003064
Synonyms:
CHEMBL1503220
Type:
Small organic molecule
Emp. Form.:
C24H22N2O4S
Mol. Mass.:
434.507
SMILES:
CCN1c2cc(ccc2[S+]([O-])c2ccccc2C1=O)C(=O)NCc1ccc(OC)cc1
Structure:
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