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Target
Glucagon receptor
Ligand
BDBM50007232
Substrate
n/a
Meas. Tech.
ChEMBL_1338729 (CHEMBL3242200)
IC50
170±n/a nM
Citation
 DeMong, D; Dai, X; Hwa, J; Miller, M; Lin, SI; Kang, L; Stamford, A; Greenlee, W; Yu, W; Wong, M; Lavey, B; Kozlowski, J; Zhou, G; Yang, DY; Patel, B; Soriano, A; Zhai, Y; Sondey, C; Zhang, H; Lachowicz, J; Grotz, D; Cox, K; Morrison, R; Andreani, T; Cao, Y; Liang, M; Meng, T; McNamara, P; Wong, J; Bradley, P; Feng, KI; Belani, J; Chen, P; Dai, P; Gauuan, J; Lin, P; Zhao, H The discovery of N-((2H-tetrazol-5-yl)methyl)-4-((R)-1-((5r,8R)-8-(tert-butyl)-3-(3,5-dichlorophenyl)-2-oxo-1,4-diazaspiro[4.5]dec-3-en-1-yl)-4,4-dimethylpentyl)benzamide (SCH 900822): a potent and selective glucagon receptor antagonist. J Med Chem 57:2601-10 (2014) [PubMed]  Article
Target
Name:
Glucagon receptor
Synonyms:
GL-R | GLR_MOUSE | Gcgr
Type:
PROTEIN
Mol. Mass.:
54941.21
Organism:
Mus musculus
Description:
ChEMBL_1338729
Residue:
485
Sequence:
MPLTQLHCPHLLLLLLVLSCLPEAPSAQVMDFLFEKWKLYSDQCHHNLSLLPPPTELVCNRTFDKYSCWPDTPPNTTANISCPWYLPWYHKVQHRLVFKRCGPDGQWVRGPRGQPWRNASQCQLDDEEIEVQKGVAKMYSSQQVMYTVGYSLSLGALLLALVILLGLRKLHCTRNYIHGNLFASFVLKAGSVLVIDWLLKTRYSQKIGDDLSVSVWLSDGAMAGCRVATVIMQYGIIANYCWLLVEGVYLYSLLSLATFSERSFFSLYLGIGWGAPLLFVIPWVVVKCLFENVQCWTSNDNMGFWWILRIPVFLALLINFFIFVHIIHLLVAKLRAHQMHYADYKFRLARSTLTLIPLLGVHEVVFAFVTDEHAQGTLRSTKLFFDLFLSSFQGLLVAVLYCFLNKEVQAELMRRWRQWQEGKALQEERLASSHGSHMAPAGPCHGDPCEKLQLMSAGSSSGTGCVPSMETSLASSLPRLADSPT
  
Inhibitor
Name:
BDBM50007232
Synonyms:
CHEMBL3238222
Type:
Small organic molecule
Emp. Form.:
C34H43F2N7O2
Mol. Mass.:
619.7477
SMILES:
CC(C)(C)CC[C@@H](N1C(=O)C(=N[C@@]11CC[C@@H](CC1)C(C)(C)C)c1ccc(F)c(F)c1)c1ccc(cc1)C(=O)NCc1nn[nH]n1 |r,wU:15.19,6.5,wD:12.13,c:10,(5.5,-43.18,;5.48,-41.64,;4.14,-40.89,;4.15,-42.4,;6.81,-40.86,;6.79,-39.32,;8.11,-38.53,;8.06,-37,;9.27,-36.05,;10.75,-36.46,;8.74,-34.6,;7.19,-34.66,;6.78,-36.14,;5.59,-35.15,;4.14,-35.68,;3.88,-37.2,;5.07,-38.19,;6.52,-37.65,;2.44,-37.73,;1.26,-36.75,;1,-38.27,;2.18,-39.25,;9.51,-33.27,;8.75,-31.93,;9.53,-30.6,;11.07,-30.61,;11.85,-29.28,;11.83,-31.95,;13.37,-31.96,;11.06,-33.28,;9.44,-39.32,;9.42,-40.86,;10.74,-41.65,;12.09,-40.9,;12.11,-39.36,;10.78,-38.57,;13.41,-41.69,;13.39,-43.23,;14.75,-40.93,;16.08,-41.72,;17.42,-40.96,;18.81,-41.6,;19.86,-40.47,;19.1,-39.13,;17.59,-39.43,)|
Structure:
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