Ki Summary

Reaction Details

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Target

Glucagon receptor

Ligand

BDBM50007435

Substrate

n/a

Meas. Tech.

ChEMBL_1338727 (CHEMBL3242198)

IC50

1100±n/a nM

Citation

DeMong, D; Dai, X; Hwa, J; Miller, M; Lin, SI; Kang, L; Stamford, A; Greenlee, W; Yu, W; Wong, M; Lavey, B; Kozlowski, J; Zhou, G; Yang, DY; Patel, B; Soriano, A; Zhai, Y; Sondey, C; Zhang, H; Lachowicz, J; Grotz, D; Cox, K; Morrison, R; Andreani, T; Cao, Y; Liang, M; Meng, T; McNamara, P; Wong, J; Bradley, P; Feng, KI; Belani, J; Chen, P; Dai, P; Gauuan, J; Lin, P; Zhao, H The discovery of N-((2H-tetrazol-5-yl)methyl)-4-((R)-1-((5r,8R)-8-(tert-butyl)-3-(3,5-dichlorophenyl)-2-oxo-1,4-diazaspiro[4.5]dec-3-en-1-yl)-4,4-dimethylpentyl)benzamide (SCH 900822): a potent and selective glucagon receptor antagonist. J Med Chem 57:2601-10 (2014) [PubMed] Article

More Info.:

Get all data from this article, Assay Method

Target

Name:

Glucagon receptor

Synonyms:

GCGR | GL-R | GLR_HUMAN | Glucagon Receptor (GCGR) | Glucagon receptor (GlucR)

Type:

Enzyme

Mol. Mass.:

54026.92

Organism:

Homo sapiens (Human)

Description:

P47871

Residue:

477

Sequence:

MPPCQPQRPLLLLLLLLACQPQVPSAQVMDFLFEKWKLYGDQCHHNLSLLPPPTELVCNRTFDKYSCWPDTPANTTANISCPWYLPWHHKVQHRFVFKRCGPDGQWVRGPRGQPWRDASQCQMDGEEIEVQKEVAKMYSSFQVMYTVGYSLSLGALLLALAILGGLSKLHCTRNAIHANLFASFVLKASSVLVIDGLLRTRYSQKIGDDLSVSTWLSDGAVAGCRVAAVFMQYGIVANYCWLLVEGLYLHNLLGLATLPERSFFSLYLGIGWGAPMLFVVPWAVVKCLFENVQCWTSNDNMGFWWILRFPVFLAILINFFIFVRIVQLLVAKLRARQMHHTDYKFRLAKSTLTLIPLLGVHEVVFAFVTDEHAQGTLRSAKLFFDLFLSSFQGLLVAVLYCFLNKEVQSELRRRWHRWRLGKVLWEERNTSNHRASSSPGHGPPSKELQFGRGGGSQDSSAETPLAGGLPRLAESPF

Inhibitor

Name:

BDBM50007435

Synonyms:

CHEMBL3237915

Type:

Small organic molecule

Emp. Form.:

C31H36F3N3O5

Mol. Mass.:

587.6298

SMILES:

C[C@@H](N1C(=O)C(=N[C@@]11CC[C@@H](CC1)C(C)(C)C)c1ccc(OC(F)(F)F)cc1)c1ccc(cc1)C(=O)NCCC(O)=O |r,wU:10.14,1.0,wD:7.8,c:5,(51.54,-26.99,;52.87,-26.21,;52.81,-24.67,;54.03,-23.72,;55.5,-24.14,;53.49,-22.27,;51.95,-22.33,;51.53,-23.81,;50.35,-22.83,;48.9,-23.36,;48.64,-24.87,;49.83,-25.86,;51.27,-25.33,;47.2,-25.41,;46.01,-24.42,;45.75,-25.94,;46.94,-26.92,;54.27,-20.94,;55.81,-20.96,;56.59,-19.62,;55.83,-18.28,;56.6,-16.95,;58.14,-16.96,;58.92,-15.63,;58.91,-18.3,;59.68,-16.96,;54.28,-18.28,;53.51,-19.61,;54.19,-26.99,;54.17,-28.54,;55.5,-29.32,;56.84,-28.57,;56.86,-27.03,;55.54,-26.25,;58.17,-29.36,;58.15,-30.9,;59.51,-28.61,;60.83,-29.39,;62.17,-28.64,;63.5,-29.42,;64.84,-28.66,;63.48,-30.96,)|

Structure: