Reaction Details  Report a problem with these data
Target
Glucagon receptor
Ligand
BDBM50007242
Substrate
n/a
Meas. Tech.
ChEMBL_1338727 (CHEMBL3242198)
IC50
66±n/a nM
Citation
 DeMong, D; Dai, X; Hwa, J; Miller, M; Lin, SI; Kang, L; Stamford, A; Greenlee, W; Yu, W; Wong, M; Lavey, B; Kozlowski, J; Zhou, G; Yang, DY; Patel, B; Soriano, A; Zhai, Y; Sondey, C; Zhang, H; Lachowicz, J; Grotz, D; Cox, K; Morrison, R; Andreani, T; Cao, Y; Liang, M; Meng, T; McNamara, P; Wong, J; Bradley, P; Feng, KI; Belani, J; Chen, P; Dai, P; Gauuan, J; Lin, P; Zhao, H The discovery of N-((2H-tetrazol-5-yl)methyl)-4-((R)-1-((5r,8R)-8-(tert-butyl)-3-(3,5-dichlorophenyl)-2-oxo-1,4-diazaspiro[4.5]dec-3-en-1-yl)-4,4-dimethylpentyl)benzamide (SCH 900822): a potent and selective glucagon receptor antagonist. J Med Chem 57:2601-10 (2014) [PubMed]  Article
Target
Name:
Glucagon receptor
Synonyms:
GCGR | GL-R | GLR_HUMAN | Glucagon Receptor (GCGR) | Glucagon receptor (GlucR)
Type:
Enzyme
Mol. Mass.:
54026.92
Organism:
Homo sapiens (Human)
Description:
P47871
Residue:
477
Sequence:
MPPCQPQRPLLLLLLLLACQPQVPSAQVMDFLFEKWKLYGDQCHHNLSLLPPPTELVCNRTFDKYSCWPDTPANTTANISCPWYLPWHHKVQHRFVFKRCGPDGQWVRGPRGQPWRDASQCQMDGEEIEVQKEVAKMYSSFQVMYTVGYSLSLGALLLALAILGGLSKLHCTRNAIHANLFASFVLKASSVLVIDGLLRTRYSQKIGDDLSVSTWLSDGAVAGCRVAAVFMQYGIVANYCWLLVEGLYLHNLLGLATLPERSFFSLYLGIGWGAPMLFVVPWAVVKCLFENVQCWTSNDNMGFWWILRFPVFLAILINFFIFVRIVQLLVAKLRARQMHHTDYKFRLAKSTLTLIPLLGVHEVVFAFVTDEHAQGTLRSAKLFFDLFLSSFQGLLVAVLYCFLNKEVQSELRRRWHRWRLGKVLWEERNTSNHRASSSPGHGPPSKELQFGRGGGSQDSSAETPLAGGLPRLAESPF
  
Inhibitor
Name:
BDBM50007242
Synonyms:
CHEMBL3238230
Type:
Small organic molecule
Emp. Form.:
C32H39Cl2N7O2
Mol. Mass.:
624.604
SMILES:
CC[C@H]1CC[C@]2(CC1)N=C(C(=O)N2[C@H](CCC(C)(C)C)c1ccc(cc1)C(=O)NCc1nn[nH]n1)c1cc(Cl)cc(Cl)c1 |r,wU:13.15,2.1,wD:5.4,c:9,(48.37,-10.14,;48.38,-8.6,;49.72,-7.84,;49.98,-6.32,;51.43,-5.79,;52.62,-6.77,;52.36,-8.29,;50.91,-8.82,;53.03,-5.29,;54.58,-5.23,;55.11,-6.68,;56.59,-7.1,;53.9,-7.63,;53.95,-9.17,;52.63,-9.95,;52.65,-11.49,;51.32,-12.28,;51.34,-13.82,;49.98,-11.53,;49.98,-13.03,;55.28,-9.95,;55.26,-11.5,;56.58,-12.28,;57.93,-11.53,;57.95,-9.99,;56.62,-9.21,;59.25,-12.32,;59.23,-13.86,;60.59,-11.57,;61.91,-12.35,;63.26,-11.6,;64.65,-12.24,;65.7,-11.1,;64.94,-9.76,;63.43,-10.06,;55.35,-3.9,;54.59,-2.57,;55.37,-1.24,;54.6,.1,;56.91,-1.24,;57.67,-2.59,;59.21,-2.6,;56.9,-3.92,)|
Structure:
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