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Target
Histone deacetylase 11
Ligand
BDBM50008222
Substrate
n/a
Meas. Tech.
ChEMBL_1339176 (CHEMBL3243339)
IC50
1770±n/a nM
Citation
 Taddei, M; Ferrini, S; Giannotti, L; Corsi, M; Manetti, F; Giannini, G; Vesci, L; Milazzo, FM; Alloatti, D; Guglielmi, MB; Castorina, M; Cervoni, ML; Barbarino, M; Foderà, R; Carollo, V; Pisano, C; Armaroli, S; Cabri, W Synthesis and evaluation of new Hsp90 inhibitors based on a 1,4,5-trisubstituted 1,2,3-triazole scaffold. J Med Chem 57:2258-74 (2014) [PubMed]  Article
Target
Name:
Histone deacetylase 11
Synonyms:
HD11 | HDA11_HUMAN | HDAC11 | Human HDAC11
Type:
Chromatin regulator; hydrolase; repressor
Mol. Mass.:
39187.66
Organism:
Homo sapiens (Human)
Description:
Q96DB2
Residue:
347
Sequence:
MLHTTQLYQHVPETRWPIVYSPRYNITFMGLEKLHPFDAGKWGKVINFLKEEKLLSDSMLVEAREASEEDLLVVHTRRYLNELKWSFAVATITEIPPVIFLPNFLVQRKVLRPLRTQTGGTIMAGKLAVERGWAINVGGGFHHCSSDRGGGFCAYADITLAIKFLFERVEGISRATIIDLDAHQGNGHERDFMDDKRVYIMDVYNRHIYPGDRFAKQAIRRKVELEWGTEDDEYLDKVERNIKKSLQEHLPDVVVYNAGTDILEGDRLGGLSISPAGIVKRDELVFRMVRGRRVPILMVTSGGYQKRTARIIADSILNLFGLGLIGPESPSVSAQNSDTPLLPPAVP
  
Inhibitor
Name:
BDBM50008222
Synonyms:
CHEMBL3235118
Type:
Small organic molecule
Emp. Form.:
C30H40N6O6
Mol. Mass.:
580.6752
SMILES:
CC(C)c1cc(c(O)cc1O)-n1nnc(C(=O)NCCCCCCC(=O)NO)c1-c1ccc(CN2CCOCC2)cc1
Structure:
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