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Target
Delta-type opioid receptor
Ligand
BDBM50010488
Substrate
n/a
Meas. Tech.
ChEMBL_1353485 (CHEMBL3269821)
Ki
6.4±n/a nM
Citation
 Ballet, S; Betti, C; Novoa, A; Tömböly, C; Nielsen, CU; Helms, HC; Lesniak, A; Kleczkowska, P; Chung, NN; Lipkowski, AW; Brodin, B; Tourwé, D; Schiller, PW In Vitro Membrane Permeation Studies and in Vivo Antinociception of Glycosylated Dmt ACS Med Chem Lett 5:352-357 (2014) [PubMed]  Article
Target
Name:
Delta-type opioid receptor
Synonyms:
Cytochrome P450 3A4 | DOR-1 | Delta opioid receptor | Delta-type opioid receptor | Delta-type opioid receptor (DOR) | OPIATE Delta | OPRD_RAT | Opiate Delta 1 | Opioid receptor | Opioid receptor A | Opioid receptors; mu & delta | Oprd1 | Ror-a | Voltage-gated potassium channel
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
40465.04
Organism:
Rattus norvegicus (rat)
Description:
Competition binding assays were using CHO-K1 cell membranes expressing the opioid receptor.
Residue:
372
Sequence:
MEPVPSARAELQFSLLANVSDTFPSAFPSASANASGSPGARSASSLALAIAITALYSAVCAVGLLGNVLVMFGIVRYTKLKTATNIYIFNLALADALATSTLPFQSAKYLMETWPFGELLCKAVLSIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPAKAKLINICIWVLASGVGVPIMVMAVTQPRDGAVVCTLQFPSPSWYWDTVTKICVFLFAFVVPILIITVCYGLMLLRLRSVRLLSGSKEKDRSLRRITRMVLVVVGAFVVCWAPIHIFVIVWTLVDINRRDPLVVAALHLCIALGYANSSLNPVLYAFLDENFKRCFRQLCRAPCGGQEPGSLRRPRQATARERVTACTPSDGPGGGAAA
  
Inhibitor
Name:
BDBM50010488
Synonyms:
CHEMBL3264361
Type:
Small organic molecule
Emp. Form.:
C38H55N11O11
Mol. Mass.:
841.9104
SMILES:
Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](COCc1cn(nn1)[C@@H]1O[C@H](CO)[C@H](O)[C@H](O)[C@H]1O)C(N)=O |r|
Structure:
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