Reaction Details  Report a problem with these data
Target
Free fatty acid receptor 1
Ligand
BDBM50010923
Substrate
n/a
Meas. Tech.
ChEMBL_1351094 (CHEMBL3270083)
EC50
19±n/a nM
Citation
 Du, X; Dransfield, PJ; Lin, DC; Wong, S; Wang, Y; Wang, Z; Kohn, T; Yu, M; Brown, SP; Vimolratana, M; Zhu, L; Li, AR; Su, Y; Jiao, X; Liu, JJ; Swaminath, G; Tran, T; Luo, J; Zhuang, R; Zhang, J; Guo, Q; Li, F; Connors, R; Medina, JC; Houze, JB Improving the Pharmacokinetics of GPR40/FFA1 Full Agonists. ACS Med Chem Lett 5:384-9 (2014) [PubMed]  Article
Target
Name:
Free fatty acid receptor 1
Synonyms:
FFAR1 | FFAR1_HUMAN | G-protein Coupled Receptor 40 | GPR40
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
31473.32
Organism:
Homo sapiens (Human)
Description:
O14842
Residue:
300
Sequence:
MDLPPQLSFGLYVAAFALGFPLNVLAIRGATAHARLRLTPSLVYALNLGCSDLLLTVSLPLKAVEALASGAWPLPASLCPVFAVAHFFPLYAGGGFLAALSAGRYLGAAFPLGYQAFRRPCYSWGVCAAIWALVLCHLGLVFGLEAPGGWLDHSNTSLGINTPVNGSPVCLEAWDPASAGPARFSLSLLLFFLPLAITAFCYVGCLRALARSGLTHRRKLRAAWVAGGALLTLLLCVGPYNASNVASFLYPNLGGSWRKLGLITGAWSVVLNPLVTGYLGRGPGLKTVCAARTQGGKSQK
  
Inhibitor
Name:
BDBM50010923
Synonyms:
CHEMBL3265146
Type:
Small organic molecule
Emp. Form.:
C29H33FN2O4
Mol. Mass.:
492.5817
SMILES:
COc1cc(c(F)cn1)-c1ccc(COc2cc(ccn2)[C@H](C)CC(O)=O)cc1[C@@H]1CCCC1(C)C |r|
Structure:
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