Reaction Details  Report a problem with these data
Target
5-hydroxytryptamine receptor 7
Ligand
BDBM50015018
Substrate
n/a
Meas. Tech.
ChEMBL_1349423 (CHEMBL3270013)
Ki
252±n/a nM
Citation
 Spadoni, G; Bedini, A; Bartolucci, S; Pala, D; Mor, M; Riccioni, T; Borsini, F; Cabri, W; Celona, D; Marzi, M; Tarzia, G; Rivara, S; Minetti, P Towards the development of 5-HT7 ligands combining serotonin-like and arylpiperazine moieties. Eur J Med Chem 80:8-35 (2014) [PubMed]  Article
Target
Name:
5-hydroxytryptamine receptor 7
Synonyms:
5-HT-7 | 5-HT-X | 5-HT7 | 5-HT7L | 5-HT7S | 5-HT7b | 5HT7 | 5HT7R_HUMAN | HTR7 | Serotonin receptor 7
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
53573.08
Organism:
Homo sapiens (Human)
Description:
P34969
Residue:
479
Sequence:
MMDVNSSGRPDLYGHLRSFLLPEVGRGLPDLSPDGGADPVAGSWAPHLLSEVTASPAPTWDAPPDNASGCGEQINYGRVEKVVIGSILTLITLLTIAGNCLVVISVCFVKKLRQPSNYLIVSLALADLSVAVAVMPFVSVTDLIGGKWIFGHFFCNVFIAMDVMCCTASIMTLCVISIDRYLGITRPLTYPVRQNGKCMAKMILSVWLLSASITLPPLFGWAQNVNDDKVCLISQDFGYTIYSTAVAFYIPMSVMLFMYYQIYKAARKSAAKHKFPGFPRVEPDSVIALNGIVKLQKEVEECANLSRLLKHERKNISIFKREQKAATTLGIIVGAFTVCWLPFFLLSTARPFICGTSCSCIPLWVERTFLWLGYANSLINPFIYAFFNRDLRTTYRSLLQCQYRNINRKLSAAGMHEALKLAERPERPEFVLRACTRRVLLRPEKRPPVSVWVLQSPDHHNWLADKMLTTVEKKVMIHD
  
Inhibitor
Name:
BDBM50015018
Synonyms:
CHEMBL3262404
Type:
Small organic molecule
Emp. Form.:
C18H23N3O
Mol. Mass.:
297.3947
SMILES:
Oc1cccc(NCCN2CCN(CC2)c2ccccc2)c1
Structure:
Search PDB for entries with ligand similarity: