Reaction Details  Report a problem with these data
Target
Histone deacetylase 8
Ligand
BDBM50015233
Substrate
n/a
Meas. Tech.
ChEMBL_1349601 (CHEMBL3266025)
IC50
1390±n/a nM
Citation
 Lee, HY; Tsai, AC; Chen, MC; Shen, PJ; Cheng, YC; Kuo, CC; Pan, SL; Liu, YM; Liu, JF; Yeh, TK; Wang, JC; Chang, CY; Chang, JY; Liou, JP Azaindolylsulfonamides, with a more selective inhibitory effect on histone deacetylase 6 activity, exhibit antitumor activity in colorectal cancer HCT116 cells. J Med Chem 57:4009-22 (2014) [PubMed]  Article
Target
Name:
Histone deacetylase 8
Synonyms:
HD8 | HDAC8 | HDAC8_HUMAN | HDACL1 | Histone deacetylase 8 (HDAC-8) | Human HDAC8
Type:
Enzyme
Mol. Mass.:
41749.60
Organism:
Homo sapiens (Human)
Description:
Q9BY41
Residue:
377
Sequence:
MEEPEEPADSGQSLVPVYIYSPEYVSMCDSLAKIPKRASMVHSLIEAYALHKQMRIVKPKVASMEEMATFHTDAYLQHLQKVSQEGDDDHPDSIEYGLGYDCPATEGIFDYAAAIGGATITAAQCLIDGMCKVAINWSGGWHHAKKDEASGFCYLNDAVLGILRLRRKFERILYVDLDLHHGDGVEDAFSFTSKVMTVSLHKFSPGFFPGTGDVSDVGLGKGRYYSVNVPIQDGIQDEKYYQICESVLKEVYQAFNPKAVVLQLGADTIAGDPMCSFNMTPVGIGKCLKYILQWQLATLILGGGGYNLANTARCWTYLTGVILGKTLSSEIPDHEFFTAYGPDYVLEITPSCRPDRNEPHRIQQILNYIKGNLKHVV
  
Inhibitor
Name:
BDBM50015233
Synonyms:
CHEMBL3262727
Type:
Small organic molecule
Emp. Form.:
C16H13N3O4S
Mol. Mass.:
343.357
SMILES:
ONC(=O)\C=C\c1cccc(c1)S(=O)(=O)n1ccc2cccnc12
Structure:
Search PDB for entries with ligand similarity: