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Target
11-beta-hydroxysteroid dehydrogenase 1
Ligand
BDBM50016984
Substrate
n/a
Meas. Tech.
ChEMBL_1364777 (CHEMBL3294285)
IC50
287±n/a nM
Citation
 Scott, JS; Goldberg, FW; Turnbull, AV Medicinal chemistry of inhibitors of 11ß-hydroxysteroid dehydrogenase type 1 (11ß-HSD1). J Med Chem 57:4466-86 (2014) [PubMed]  Article
Target
Name:
11-beta-hydroxysteroid dehydrogenase 1
Synonyms:
11-DH | 11-beta-HSD1 | 11-beta-Hydroxysteroid Dehydrogenase 1 (11-beta-HSD1) | 11-beta-hydroxysteroid dehydrogenase 1 | Corticosteroid 11-beta-dehydrogenase isozyme 1 | Corticosteroid 11-beta-dehydrogenase isozyme 1 (11-beta-HSD-1) | DHI1_RAT | Hsd11 | Hsd11b1
Type:
Enzyme
Mol. Mass.:
31889.48
Organism:
Rattus norvegicus (rat)
Description:
P16232
Residue:
288
Sequence:
MKKYLLPVLVLCLGYYYSTNEEFRPEMLQGKKVIVTGASKGIGREMAYHLSKMGAHVVLTARSEEGLQKVVSRCLELGAASAHYIAGTMEDMAFAERFVVEAGKLLGGLDMLILNHITQTTMSLFHDDIHSVRRSMEVNFLSYVVLSTAALPMLKQSNGSIAIISSMAGKMTQPLIASYSASKFALDGFFSTIRKEHLMTKVNVSITLCVLGFIDTETALKETSGIILSQAAPKEECALEIIKGTVLRKDEVYYDKSSWTPLLLGNPGRRIMEFLSLRSYNRDLFVSN
  
Inhibitor
Name:
BDBM50016984
Synonyms:
CHEMBL3287029
Type:
Small organic molecule
Emp. Form.:
C23H35N3O4S2
Mol. Mass.:
481.672
SMILES:
[H][C@]12CCCC[C@@]1([H])N(CCC2)C(=O)c1csc(c1)C1CCN(CC1)C(=O)CCNS(C)(=O)=O |r|
Structure:
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