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Target
11-beta-hydroxysteroid dehydrogenase 1
Ligand
BDBM50239276
Substrate
n/a
Meas. Tech.
ChEMBL_1364745 (CHEMBL3294006)
IC50
109±n/a nM
Citation
 Scott, JS; Goldberg, FW; Turnbull, AV Medicinal chemistry of inhibitors of 11ß-hydroxysteroid dehydrogenase type 1 (11ß-HSD1). J Med Chem 57:4466-86 (2014) [PubMed]  Article
Target
Name:
11-beta-hydroxysteroid dehydrogenase 1
Synonyms:
11-DH | 11-beta-HSD1 | 11-beta-Hydroxysteroid Dehydrogenase 1 (11-beta-HSD1) | 11-beta-hydroxysteroid dehydrogenase 1 | 11beta-HSD1A | Corticosteroid 11-beta-dehydrogenase isozyme 1 | Corticosteroid 11-beta-dehydrogenase isozyme 1 (11-beta-HSD-1) | DHI1_MOUSE | Hsd11 | Hsd11b1
Type:
Enzyme
Mol. Mass.:
32369.70
Organism:
Mus musculus (mouse)
Description:
P50172
Residue:
292
Sequence:
MAVMKNYLLPILVLFLAYYYYSTNEEFRPEMLQGKKVIVTGASKGIGREMAYHLSKMGAHVVLTARSEEGLQKVVSRCLELGAASAHYIAGTMEDMTFAEQFIVKAGKLMGGLDMLILNHITQTSLSLFHDDIHSVRRVMEVNFLSYVVMSTAALPMLKQSNGSIAVISSLAGKMTQPMIAPYSASKFALDGFFSTIRTELYITKVNVSITLCVLGLIDTETAMKEISGIINAQASPKEECALEIIKGTALRKSEVYYDKSPLTPILLGNPGRKIMEFFSLRYYNKDMFVSN
  
Inhibitor
Name:
BDBM50239276
Synonyms:
3-Adamantan-1-yl-4-methyl-5-phenyl-4H-[1,2,4]triazole | CHEMBL428429
Type:
Small organic molecule
Emp. Form.:
C19H23N3
Mol. Mass.:
293.406
SMILES:
Cn1c(nnc1C12CC3CC(CC(C3)C1)C2)-c1ccccc1 |TLB:9:10:8.7.13:14,THB:9:8:10.15.11:14,11:10:7:13.12.14,11:12:9.10.15:7|
Structure:
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