Reaction Details  Report a problem with these data
Target
Pyroglutamylated RF-amide peptide receptor
Ligand
BDBM50019980
Substrate
n/a
Meas. Tech.
ChEMBL_1363386 (CHEMBL3295521)
IC50
1585±n/a nM
Citation
 Nordqvist, A; Kristensson, L; Johansson, KE; Isaksson da Silva, K; Fex, T; Tyrchan, C; Svensson Henriksson, A; Nilsson, K New Hits as Antagonists of GPR103 Identified by HTS. ACS Med Chem Lett 5:527-32 (2014) [PubMed]  Article
Target
Name:
Pyroglutamylated RF-amide peptide receptor
Synonyms:
GPR103 | Pyroglutamylated RFamide peptide receptor | QRFPR | QRFPR_HUMAN
Type:
Enzyme Catalytic Domain
Mol. Mass.:
49508.46
Organism:
Homo sapiens (Human)
Description:
GPR103 0 HUMAN::Q96P65
Residue:
431
Sequence:
MQALNITPEQFSRLLRDHNLTREQFIALYRLRPLVYTPELPGRAKLALVLTGVLIFALALFGNALVFYVVTRSKAMRTVTNIFICSLALSDLLITFFCIPVTMLQNISDNWLGGAFICKMVPFVQSTAVVTEILTMTCIAVERHQGLVHPFKMKWQYTNRRAFTMLGVVWLVAVIVGSPMWHVQQLEIKYDFLYEKEHICCLEEWTSPVHQKIYTTFILVILFLLPLMVMLILYSKIGYELWIKKRVGDGSVLRTIHGKEMSKIARKKKRAVIMMVTVVALFAVCWAPFHVVHMMIEYSNFEKEYDDVTIKMIFAIVQIIGFSNSICNPIVYAFMNENFKKNVLSAVCYCIVNKTFSPAQRHGNSGITMMRKKAKFSLRENPVEETKGEAFSDGNIEVKLCEQTEEKKKLKRHLALFRSELAENSPLDSGH
  
Inhibitor
Name:
BDBM50019980
Synonyms:
CHEMBL3287834
Type:
Small organic molecule
Emp. Form.:
C21H20N2OS
Mol. Mass.:
348.461
SMILES:
COc1ccc(NC(=N)c2ccccc2)cc1CSc1ccccc1
Structure:
Search PDB for entries with ligand similarity: