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Target
Serine/threonine-protein kinase Sgk1
Ligand
BDBM50043017
Substrate
n/a
Meas. Tech.
ChEMBL_1444807 (CHEMBL3379050)
IC50
<1.5±n/a nM
Citation
 Rosse, G Novel azaindazole sulfonamides inhibitors of serum and glucocorticoid regulated kinase. ACS Med Chem Lett 6:19-20 (2015) [PubMed]  Article
Target
Name:
Serine/threonine-protein kinase Sgk1
Synonyms:
SGK | SGK1 | SGK1_HUMAN | Serine/threonine-protein kinase Sgk1 | Serine/threonine-protein kinase Sgk1 (SGK) | Serum/glucocorticoid regulated kinase | Serum/glucocorticoid-regulated kinase 1 (SGK1)
Type:
Other Protein Type
Mol. Mass.:
48954.40
Organism:
Homo sapiens (Human)
Description:
Recombinant human SGK-1 enzyme produced in a baculovirus system.
Residue:
431
Sequence:
MTVKTEAAKGTLTYSRMRGMVAILIAFMKQRRMGLNDFIQKIANNSYACKHPEVQSILKISQPQEPELMNANPSPPPSPSQQINLGPSSNPHAKPSDFHFLKVIGKGSFGKVLLARHKAEEVFYAVKVLQKKAILKKKEEKHIMSERNVLLKNVKHPFLVGLHFSFQTADKLYFVLDYINGGELFYHLQRERCFLEPRARFYAAEIASALGYLHSLNIVYRDLKPENILLDSQGHIVLTDFGLCKENIEHNSTTSTFCGTPEYLAPEVLHKQPYDRTVDWWCLGAVLYEMLYGLPPFYSRNTAEMYDNILNKPLQLKPNITNSARHLLEGLLQKDRTKRLGAKDDFMEIKSHVFFSLINWDDLINKKITPPFNPNVSGPNDLRHFDPEFTEEPVPNSIGKSPDSVLVTASVKEAAEAFLGFSYAPPTDSFL
  
Inhibitor
Name:
BDBM50043017
Synonyms:
CHEMBL3355027
Type:
Small organic molecule
Emp. Form.:
C24H21ClN6O4S
Mol. Mass.:
524.979
SMILES:
OC1CCC(CC1)Oc1nc(nc2[nH]ncc12)-c1ccc(NS(=O)(=O)c2cc(Cl)ccc2C#N)cc1 |(68.02,-2.5,;66.48,-2.49,;65.7,-3.83,;64.16,-3.83,;63.39,-2.48,;64.16,-1.15,;65.7,-1.16,;61.85,-2.48,;61.08,-3.82,;59.54,-3.83,;58.77,-5.16,;59.54,-6.5,;61.08,-6.49,;62.1,-7.64,;63.51,-7.03,;63.36,-5.5,;61.86,-5.17,;57.23,-5.15,;56.46,-6.49,;54.91,-6.48,;54.15,-5.14,;52.61,-5.13,;51.84,-6.46,;53.17,-7.23,;51.83,-8,;50.29,-6.47,;49.52,-5.14,;47.98,-5.14,;47.2,-3.81,;47.22,-6.47,;47.99,-7.8,;49.53,-7.8,;50.3,-9.14,;51.07,-10.47,;54.92,-3.81,;56.46,-3.81,)|
Structure:
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