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Target
Serine/threonine-protein kinase Sgk1
Ligand
BDBM50043022
Substrate
n/a
Meas. Tech.
ChEMBL_1444807 (CHEMBL3379050)
IC50
6.5±n/a nM
Citation
 Rosse, G Novel azaindazole sulfonamides inhibitors of serum and glucocorticoid regulated kinase. ACS Med Chem Lett 6:19-20 (2015) [PubMed]  Article
Target
Name:
Serine/threonine-protein kinase Sgk1
Synonyms:
SGK | SGK1 | SGK1_HUMAN | Serine/threonine-protein kinase Sgk1 | Serine/threonine-protein kinase Sgk1 (SGK) | Serum/glucocorticoid regulated kinase | Serum/glucocorticoid-regulated kinase 1 (SGK1)
Type:
Other Protein Type
Mol. Mass.:
48954.40
Organism:
Homo sapiens (Human)
Description:
Recombinant human SGK-1 enzyme produced in a baculovirus system.
Residue:
431
Sequence:
MTVKTEAAKGTLTYSRMRGMVAILIAFMKQRRMGLNDFIQKIANNSYACKHPEVQSILKISQPQEPELMNANPSPPPSPSQQINLGPSSNPHAKPSDFHFLKVIGKGSFGKVLLARHKAEEVFYAVKVLQKKAILKKKEEKHIMSERNVLLKNVKHPFLVGLHFSFQTADKLYFVLDYINGGELFYHLQRERCFLEPRARFYAAEIASALGYLHSLNIVYRDLKPENILLDSQGHIVLTDFGLCKENIEHNSTTSTFCGTPEYLAPEVLHKQPYDRTVDWWCLGAVLYEMLYGLPPFYSRNTAEMYDNILNKPLQLKPNITNSARHLLEGLLQKDRTKRLGAKDDFMEIKSHVFFSLINWDDLINKKITPPFNPNVSGPNDLRHFDPEFTEEPVPNSIGKSPDSVLVTASVKEAAEAFLGFSYAPPTDSFL
  
Inhibitor
Name:
BDBM50043022
Synonyms:
CHEMBL3355032
Type:
Small organic molecule
Emp. Form.:
C21H18FN5O2S
Mol. Mass.:
423.463
SMILES:
Cc1ccc(F)c(c1)S(=O)(=O)Nc1ccc(cc1)-c1nc(C2CC2)c2cn[nH]c2n1
Structure:
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