Reaction Details  Report a problem with these data
Target
Cathepsin B
Ligand
BDBM91550
Substrate
n/a
Meas. Tech.
ChEMBL_1459865 (CHEMBL3367288)
Ki
1365±n/a nM
Citation
 Raghav, N; Singh, M SAR studies of differently functionalized chalcones based hydrazones and their cyclized derivatives as inhibitors of mammalian cathepsin B and cathepsin H. Bioorg Med Chem 22:4233-45 (2014) [PubMed]  Article
Target
Name:
Cathepsin B
Synonyms:
n/a
Type:
Protein
Mol. Mass.:
36777.57
Organism:
Capra hircus (Goat)
Description:
n/a
Residue:
335
Sequence:
MWQLLATLSCLLVLTSARSSLHFPPLSDEMVNYVNKQNTTWKAGHNFYNVDLSYVKKLCGAILGGPKLPQRDAFAADMVLPDSFDAREQWPNCPTIKEIRDQGSCGSCWAFGAVEAISDRICIHSKGRVNVEVSAEDMLTCCGSECGDGCNGGFPSGAWNFWTKKGLVSGGLYDSHVGCRPYSIPPCEHHVNGSRPPCTGEGDTPKCSKICEPGYSPSYKDDKHFGCSSYSVSSNEKEIMAEIYKNGPVEGAFSVYSDFLLYKSGVYQHVSGEMMGGHAIRILGWGVENDTPYWLVGNSWNTDWGDKGFFKILRGQDHCGIESEIVAGMPCTHQY
  
Inhibitor
Name:
BDBM91550
Synonyms:
1,3-diphenyl-5-(p-tolyl)-2-pyrazoline | 3-(4-methylphenyl)-2,5-diphenyl-3,4-dihydropyrazole | VU0466988-1 | cid_2729183
Type:
Small organic molecule
Emp. Form.:
C22H20N2
Mol. Mass.:
312.4076
SMILES:
Cc1ccc(cc1)C1CC(=NN1c1ccccc1)c1ccccc1 |c:10|
Structure:
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