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Target
Monoglyceride lipase
Ligand
BDBM50438779
Substrate
n/a
Meas. Tech.
ChEMBL_1453719 (CHEMBL3364121)
IC50
>100000±n/a nM
Citation
 Hajdu, Z; Nicolussi, S; Rau, M; Lorántfy, L; Forgo, P; Hohmann, J; Csupor, D; Gertsch, J Identification of endocannabinoid system-modulating N-alkylamides from Heliopsis helianthoides var. scabra and Lepidium meyenii. J Nat Prod 77:1663-9 (2014) [PubMed]  Article
Target
Name:
Monoglyceride lipase
Synonyms:
MAG lipase | MGLL_MOUSE | Mgll | Monoacylglycerol lipase | Monoglyceride Lipase (MGL)
Type:
Hydrolase
Mol. Mass.:
33391.67
Organism:
Mus musculus (mouse)
Description:
Assays were using membranes of recombinant MAG Lipase transiently transfected in COS-7 cells.
Residue:
303
Sequence:
MPEASSPRRTPQNVPYQDLPHLVNADGQYLFCRYWKPSGTPKALIFVSHGAGEHCGRYDELAHMLKGLDMLVFAHDHVGHGQSEGERMVVSDFQVFVRDVLQHVDTIQKDYPDVPIFLLGHSMGGAISILVAAERPTYFSGMVLISPLVLANPESASTLKVLAAKLLNFVLPNMTLGRIDSSVLSRNKSEVDLYNSDPLVCRAGLKVCFGIQLLNAVARVERAMPRLTLPFLLLQGSADRLCDSKGAYLLMESSRSQDKTLKMYEGAYHVLHRELPEVTNSVLHEVNSWVSHRIAAAGAGCPP
  
Inhibitor
Name:
BDBM50438779
Synonyms:
CHEMBL2413161
Type:
Small organic molecule
Emp. Form.:
C25H37NO
Mol. Mass.:
367.5674
SMILES:
CC\C=C/C\C=C/C\C=C/CCCCCCCC(=O)NCc1ccccc1
Structure:
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