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Target
Indoleamine 2,3-dioxygenase 1
Ligand
BDBM50051848
Substrate
n/a
Meas. Tech.
ChEMBL_1452147 (CHEMBL3365093)
IC50
1800±n/a nM
Citation
 Röhrig, UF; Majjigapu, SR; Chambon, M; Bron, S; Pilotte, L; Colau, D; Van den Eynde, BJ; Turcatti, G; Vogel, P; Zoete, V; Michielin, O Detailed analysis and follow-up studies of a high-throughput screening for indoleamine 2,3-dioxygenase 1 (IDO1) inhibitors. Eur J Med Chem 84:284-301 (2014) [PubMed]  Article
Target
Name:
Indoleamine 2,3-dioxygenase 1
Synonyms:
I23O1_HUMAN | IDO | IDO-1 | IDO1 | INDO | Indoleamine 2,3-Dioxygenasae (IDO) | Indoleamine 2,3-dioxygenase | Indoleamine-pyrrole 2,3-dioxygenase
Type:
Enzyme
Mol. Mass.:
45330.80
Organism:
Homo sapiens (Human)
Description:
P14902
Residue:
403
Sequence:
MAHAMENSWTISKEYHIDEEVGFALPNPQENLPDFYNDWMFIAKHLPDLIESGQLRERVEKLNMLSIDHLTDHKSQRLARLVLGCITMAYVWGKGHGDVRKVLPRNIAVPYCQLSKKLELPPILVYADCVLANWKKKDPNKPLTYENMDVLFSFRDGDCSKGFFLVSLLVEIAAASAIKVIPTVFKAMQMQERDTLLKALLEIASCLEKALQVFHQIHDHVNPKAFFSVLRIYLSGWKGNPQLSDGLVYEGFWEDPKEFAGGSAGQSSVFQCFDVLLGIQQTAGGGHAAQFLQDMRRYMPPAHRNFLCSLESNPSVREFVLSKGDAGLREAYDACVKALVSLRSYHLQIVTKYILIPASQQPKENKTSEDPSKLEAKGTGGTDLMNFLKTVRSTTEKSLLKEG
  
Inhibitor
Name:
BDBM50051848
Synonyms:
CHEMBL3318329
Type:
Small organic molecule
Emp. Form.:
C12H8N2O3
Mol. Mass.:
228.2035
SMILES:
COC(=O)C(\C#N)=C1\C(=O)Nc2ccccc12
Structure:
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