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Target
Myeloblastin
Ligand
BDBM50063048
Substrate
n/a
Meas. Tech.
ChEMBL_1463425 (CHEMBL3399762)
IC50
2050±n/a nM
Citation
 Hwang, TL; Wang, WH; Wang, TY; Yu, HP; Hsieh, PW Synthesis and pharmacological characterization of 2-aminobenzaldehyde oxime analogs as dual inhibitors of neutrophil elastase and proteinase 3. Bioorg Med Chem 23:1123-34 (2015) [PubMed]  Article
Target
Name:
Myeloblastin
Synonyms:
Leukocyte proteinase 3 | MBN | PRTN3 | PRTN3_HUMAN
Type:
PROTEIN
Mol. Mass.:
27816.30
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1463425
Residue:
256
Sequence:
MAHRPPSPALASVLLALLLSGAARAAEIVGGHEAQPHSRPYMASLQMRGNPGSHFCGGTLIHPSFVLTAAHCLRDIPQRLVNVVLGAHNVRTQEPTQQHFSVAQVFLNNYDAENKLNDVLLIQLSSPANLSASVATVQLPQQDQPVPHGTQCLAMGWGRVGAHDPPAQVLQELNVTVVTFFCRPHNICTFVPRRKAGICFGDSGGPLICDGIIQGIDSFVIWGCATRLFPDFFTRVALYVDWIRSTLRRVEAKGRP
  
Inhibitor
Name:
BDBM50063048
Synonyms:
CHEMBL3398147
Type:
Small organic molecule
Emp. Form.:
C18H19NO5S
Mol. Mass.:
361.412
SMILES:
CC(C)(C)C(=O)Oc1ccc(cc1)S(=O)(=O)Nc1ccccc1C=O
Structure:
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