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Target
Oligo-1,6-glucosidase IMA1
Ligand
BDBM50063768
Substrate
n/a
Meas. Tech.
ChEMBL_1463722 (CHEMBL3399253)
IC50
111500±n/a nM
Citation
 Han, K; Li, Y; Zhang, Y; Teng, Y; Ma, Y; Wang, M; Wang, R; Xu, W; Yao, Q; Zhang, Y; Qin, H; Sun, H; Yu, P Design, synthesis and docking study of novel tetracyclic oxindole derivatives asa-glucosidase inhibitors. Bioorg Med Chem Lett 25:1471-5 (2015) [PubMed]  Article
Target
Name:
Oligo-1,6-glucosidase IMA1
Synonyms:
α-glucosidase | Alpha-glucosidase | Alpha-glucosidase (α-glucosidase) | IMA1 | MALX3_YEAST | Oligo-1,6-glucosidase
Type:
Protein
Mol. Mass.:
68577.59
Organism:
Saccharomyces cerevisiae S288c (Baker's yeast)
Description:
n/a
Residue:
589
Sequence:
MTISSAHPETEPKWWKEATFYQIYPASFKDSNDDGWGDMKGIASKLEYIKELGADAIWISPFYDSPQDDMGYDIANYEKVWPTYGTNEDCFALIEKTHKLGMKFITDLVINHCSSEHEWFKESRSSKTNPKRDWFFWRPPKGYDAEGKPIPPNNWKSYFGGSAWTFDEKTQEFYLRLFCSTQPDLNWENEDCRKAIYESAVGYWLDHGVDGFRIDVGSLYSKVVGLPDAPVVDKNSTWQSSDPYTLNGPRIHEFHQEMNQFIRNRVKDGREIMTVGEMQHASDETKRLYTSASRHELSELFNFSHTDVGTSPLFRYNLVPFELKDWKIALAELFRYINGTDCWSTIYLENHDQPRSITRFGDDSPKNRVISGKLLSVLLSALTGTLYVYQGQELGQINFKNWPVEKYEDVEIRNNYNAIKEEHGENSEEMKKFLEAIALISRDHARTPMQWSREEPNAGFSGPSAKPWFYLNDSFREGINVEDEIKDPNSVLNFWKEALKFRKAHKDITVYGYDFEFIDLDNKKLFSFTKKYNNKTLFAALNFSSDATDFKIPNDDSSFKLEFGNYPKKEVDASSRTLKPWEGRIYISE
  
Inhibitor
Name:
BDBM50063768
Synonyms:
CHEMBL3397469
Type:
Small organic molecule
Emp. Form.:
C27H22N2O6
Mol. Mass.:
470.4734
SMILES:
COC(=O)CC1N(C(=O)c2ccc(OC)cc2)c2ccccc2-c2ccc3N(C)C(=O)C(=O)c3c12
Structure:
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