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Target
15-hydroxyprostaglandin dehydrogenase [NAD(+)]
Ligand
BDBM50066953
Substrate
n/a
Meas. Tech.
ChEMBL_1466178 (CHEMBL3404953)
IC50
4.0±n/a nM
Citation
 Piao, YL; Ram Song, A; Cho, H Cell-based biological evaluations of 5-(3-bromo-4-phenethoxybenzylidene)thiazolidine-2,4-dione as promising wound healing agent. Bioorg Med Chem 23:2098-103 (2015) [PubMed]  Article
Target
Name:
15-hydroxyprostaglandin dehydrogenase [NAD(+)]
Synonyms:
15-PGDH | 15-hydroxyprostaglandin dehydrogenase [NAD+] | HPGD | PGDH1 | PGDH_HUMAN | Prostaglandin dehydrogenase 1 (15-PGDH) | SDR36C1
Type:
Enzyme
Mol. Mass.:
28974.46
Organism:
Homo sapiens (Human)
Description:
P15428
Residue:
266
Sequence:
MHVNGKVALVTGAAQGIGRAFAEALLLKGAKVALVDWNLEAGVQCKAALDEQFEPQKTLFIQCDVADQQQLRDTFRKVVDHFGRLDILVNNAGVNNEKNWEKTLQINLVSVISGTYLGLDYMSKQNGGEGGIIINMSSLAGLMPVAQQPVYCASKHGIVGFTRSAALAANLMNSGVRLNAICPGFVNTAILESIEKEENMGQYIEYKDHIKDMIKYYGILDPPLIANGLITLIEDDALNGAIMKITTSKGIHFQDYDTTPFQAKTQ
  
Inhibitor
Name:
BDBM50066953
Synonyms:
CHEMBL3403240
Type:
Small organic molecule
Emp. Form.:
C18H14BrNO3S
Mol. Mass.:
404.278
SMILES:
Brc1cc(\C=C2/SC(=O)NC2=O)ccc1OCCc1ccccc1
Structure:
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