Reaction Details Report a problem with these data
Target
E3 ubiquitin-protein ligase Mdm2
Ligand
BDBM50069785
Substrate
n/a
Meas. Tech.
ChEMBL_1469499 (CHEMBL3412296)
IC50
0.420000±n/a nM
Citation
Rew, Y; Sun, D; Yan, X; Beck, HP; Canon, J; Chen, A; Duquette, J; Eksterowicz, J; Fox, BM; Fu, J; Gonzalez, AZ; Houze, J; Huang, X; Jiang, M; Jin, L; Li, Y; Li, Z; Ling, Y; Lo, MC; Long, AM; McGee, LR; McIntosh, J; Oliner, JD; Osgood, T; Saiki, AY; Shaffer, P; Wang, YC; Wortman, S; Yakowec, P; Ye, Q; Yu, D; Zhao, X; Zhou, J; Medina, JC; Olson, SH Discovery of AM-7209, a potent and selective 4-amidobenzoic acid inhibitor of the MDM2-p53 interaction. J Med Chem 57:10499-511 (2014) [PubMed] Article
More Info.:
Target
Name:
E3 ubiquitin-protein ligase Mdm2
Synonyms:
Double minute 2 protein | Double minute 2 protein (HDM2) | E3 ubiquitin-protein ligase Mdm2 (p53-binding protein Mdm2) | Hdm2 | Human Double Minute 2 (HDM2) | MDM2 | MDM2-MDMX | MDM2_HUMAN | p53-Binding Protein MDM2 | p53-binding protein
Type:
Oncoprotein
Mol. Mass.:
55196.54
Organism:
Homo sapiens (Human)
Description:
Q00987
Residue:
491
Sequence:
MCNTNMSVPTDGAVTTSQIPASEQETLVRPKPLLLKLLKSVGAQKDTYTMKEVLFYLGQYIMTKRLYDEKQQHIVYCSNDLLGDLFGVPSFSVKEHRKIYTMIYRNLVVVNQQESSDSGTSVSENRCHLEGGSDQKDLVQELQEEKPSSSHLVSRPSTSSRRRAISETEENSDELSGERQRKRHKSDSISLSFDESLALCVIREICCERSSSSESTGTPSNPDLDAGVSEHSGDWLDQDSVSDQFSVEFEVESLDSEDYSLSEEGQELSDEDDEVYQVTVYQAGESDTDSFEEDPEISLADYWKCTSCNEMNPPLPSHCNRCWALRENWLPEDKGKDKGEISEKAKLENSTQAEEGFDVPDCKKTIVNDSRESCVEENDDKITQASQSQESEDYSQPSTSSSIIYSSQEDVKEFEREETQDKEESVESSLPLNAIEPCVICQGRPKNGCIVHGKTGHLMACFTCAKKLKKRNKPCPVCRQPIQMIVLTYFP
Inhibitor
Name:
BDBM50069785
Synonyms:
CHEMBL3407568
Type:
Small organic molecule
Emp. Form.:
C36H46Cl2N2O6S
Mol. Mass.:
705.731
SMILES:
CC(C)(C)S(=O)(=O)C[C@H](C1CC1)N1[C@@H]([C@H](C[C@](C)(CC(=O)N[C@H]2CC[C@H](CC2)C(O)=O)C1=O)c1cccc(Cl)c1)c1ccc(Cl)cc1 |r,wU:13.43,16.18,8.8,wD:14.35,22.22,25.29,(.26,-6,;1.33,-5.39,;1.32,-6.62,;2.39,-6.01,;1.33,-3.85,;1.33,-2.62,;.26,-3.23,;2.66,-3.08,;2.67,-1.54,;4,-.77,;5.46,-.81,;4.69,.52,;1.33,-.77,;1.33,.77,;,1.54,;-1.33,.77,;-1.33,-.77,;-2.39,-.13,;-1.3,-2.29,;-2.59,-3.13,;-3.69,-2.56,;-2.52,-4.66,;-3.81,-5.5,;-5.18,-4.79,;-6.47,-5.63,;-6.4,-7.17,;-5.03,-7.87,;-3.74,-7.04,;-7.7,-8,;-7.64,-9.23,;-8.79,-7.43,;,-1.54,;,-2.77,;,3.08,;-1.33,3.85,;-1.33,5.39,;0,6.16,;1.34,5.39,;2.41,6,;1.33,3.85,;2.67,1.54,;2.67,3.08,;4.01,3.85,;5.34,3.08,;6.41,3.69,;5.34,1.54,;4,.77,)|