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Target
E3 ubiquitin-protein ligase Mdm2
Ligand
BDBM50069798
Substrate
n/a
Meas. Tech.
ChEMBL_1469730 (CHEMBL3413418)
IC50
0.500000±n/a nM
Citation
 Rew, Y; Sun, D; Yan, X; Beck, HP; Canon, J; Chen, A; Duquette, J; Eksterowicz, J; Fox, BM; Fu, J; Gonzalez, AZ; Houze, J; Huang, X; Jiang, M; Jin, L; Li, Y; Li, Z; Ling, Y; Lo, MC; Long, AM; McGee, LR; McIntosh, J; Oliner, JD; Osgood, T; Saiki, AY; Shaffer, P; Wang, YC; Wortman, S; Yakowec, P; Ye, Q; Yu, D; Zhao, X; Zhou, J; Medina, JC; Olson, SH Discovery of AM-7209, a potent and selective 4-amidobenzoic acid inhibitor of the MDM2-p53 interaction. J Med Chem 57:10499-511 (2014) [PubMed]  Article
Target
Name:
E3 ubiquitin-protein ligase Mdm2
Synonyms:
Double minute 2 protein | Double minute 2 protein (HDM2) | E3 ubiquitin-protein ligase Mdm2 (p53-binding protein Mdm2) | Hdm2 | Human Double Minute 2 (HDM2) | MDM2 | MDM2-MDMX | MDM2_HUMAN | p53-Binding Protein MDM2 | p53-binding protein
Type:
Oncoprotein
Mol. Mass.:
55196.54
Organism:
Homo sapiens (Human)
Description:
Q00987
Residue:
491
Sequence:
MCNTNMSVPTDGAVTTSQIPASEQETLVRPKPLLLKLLKSVGAQKDTYTMKEVLFYLGQYIMTKRLYDEKQQHIVYCSNDLLGDLFGVPSFSVKEHRKIYTMIYRNLVVVNQQESSDSGTSVSENRCHLEGGSDQKDLVQELQEEKPSSSHLVSRPSTSSRRRAISETEENSDELSGERQRKRHKSDSISLSFDESLALCVIREICCERSSSSESTGTPSNPDLDAGVSEHSGDWLDQDSVSDQFSVEFEVESLDSEDYSLSEEGQELSDEDDEVYQVTVYQAGESDTDSFEEDPEISLADYWKCTSCNEMNPPLPSHCNRCWALRENWLPEDKGKDKGEISEKAKLENSTQAEEGFDVPDCKKTIVNDSRESCVEENDDKITQASQSQESEDYSQPSTSSSIIYSSQEDVKEFEREETQDKEESVESSLPLNAIEPCVICQGRPKNGCIVHGKTGHLMACFTCAKKLKKRNKPCPVCRQPIQMIVLTYFP
  
Inhibitor
Name:
BDBM50069798
Synonyms:
CHEMBL3407576
Type:
Small organic molecule
Emp. Form.:
C37H41Cl2FN2O7S
Mol. Mass.:
747.7
SMILES:
COc1cc(NC(=O)C[C@@]2(C)C[C@@H]([C@H](N([C@H](CS(=O)(=O)C(C)(C)C)C3CC3)C2=O)c2ccc(Cl)cc2)c2cccc(Cl)c2F)ccc1C(O)=O |r|
Structure:
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