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Target
Apoptosis regulator Bcl-2
Ligand
BDBM50078030
Substrate
n/a
Meas. Tech.
ChEMBL_1471767 (CHEMBL3417878)
Ki
1900±n/a nM
Citation
 Stornaiuolo, M; La Regina, G; Passacantilli, S; Grassia, G; Coluccia, A; La Pietra, V; Giustiniano, M; Cassese, H; Di Maro, S; Brancaccio, D; Taliani, S; Ialenti, A; Silvestri, R; Martini, C; Novellino, E; Marinelli, L Structure-based lead optimization and biological evaluation of BAX direct activators as novel potential anticancer agents. J Med Chem 58:2135-48 (2015) [PubMed]  Article
Target
Name:
Apoptosis regulator Bcl-2
Synonyms:
Apoptosis regulator Bcl-2 Protein | B-cell lymphoma 2 protein (Bcl-2) | BCL-2 | BCL2 | BCL2_HUMAN | Bcl-2 Protein
Type:
Homodimer or heterodimer
Mol. Mass.:
26269.11
Organism:
Homo sapiens (Human)
Description:
P10415
Residue:
239
Sequence:
MAHAGRTGYDNREIVMKYIHYKLSQRGYEWDAGDVGAAPPGAAPAPGIFSSQPGHTPHPAASRDPVARTSPLQTPAAPGAAAGPALSPVPPVVHLTLRQAGDDFSRRYRRDFAEMSSQLHLTPFTARGRFATVVEELFRDGVNWGRIVAFFEFGGVMCVESVNREMSPLVDNIALWMTEYLNRHLHTWIQDNGGWDAFVELYGPSMRPLFDFSWLSLKTLLSLALVGACITLGAYLGHK
  
Inhibitor
Name:
BDBM50078030
Synonyms:
CHEMBL3417410
Type:
Small organic molecule
Emp. Form.:
C20H15N3OS
Mol. Mass.:
345.418
SMILES:
CC1=NN(C(=O)\C1=C\c1ccccc1)c1nc(cs1)-c1ccccc1 |t:1|
Structure:
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