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Target
Neuropeptide FF receptor 1
Ligand
BDBM50082065
Substrate
n/a
Meas. Tech.
ChEMBL_1474637 (CHEMBL3423987)
EC50
222±n/a nM
Citation
 Beltramo, M; Robert, V; Galibert, M; Madinier, JB; Marceau, P; Dardente, H; Decourt, C; De Roux, N; Lomet, D; Delmas, AF; Caraty, A; Aucagne, V Rational design of triazololipopeptides analogs of kisspeptin inducing a long-lasting increase of gonadotropins. J Med Chem 58:3459-70 (2015) [PubMed]  Article
Target
Name:
Neuropeptide FF receptor 1
Synonyms:
G-protein coupled receptor 147 | GPR147 | NPFF1 | NPFF1_HUMAN | NPFFR1 | RFamide-related peptide receptor OT7T022
Type:
PROTEIN
Mol. Mass.:
47840.07
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1474637
Residue:
430
Sequence:
MEGEPSQPPNSSWPLSQNGTNTEATPATNLTFSSYYQHTSPVAAMFIVAYALIFLLCMVGNTLVCFIVLKNRHMHTVTNMFILNLAVSDLLVGIFCMPTTLVDNLITGWPFDNATCKMSGLVQGMSVSASVFTLVAIAVERFRCIVHPFREKLTLRKALVTIAVIWALALLIMCPSAVTLTVTREEHHFMVDARNRSYPLYSCWEAWPEKGMRRVYTTVLFSHIYLAPLALIVVMYARIARKLCQAPGPAPGGEEAADPRASRRRARVVHMLVMVALFFTLSWLPLWALLLLIDYGQLSAPQLHLVTVYAFPFAHWLAFFNSSANPIIYGYFNENFRRGFQAAFRARLCPRPSGSHKEAYSERPGGLLHRRVFVVVRPSDSGLPSESGPSSGAPRPGRLPLRNGRVAHHGLPREGPGCSHLPLTIPAWDI
  
Inhibitor
Name:
BDBM50082065
Synonyms:
CHEMBL3422516
Type:
Small organic molecule
Emp. Form.:
C89H128N20O18
Mol. Mass.:
1766.0918
SMILES:
CCCCCCCCCCCCCCCC(=O)N[C@@H](CCC(=O)NCCCC[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(C)=O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccccc1)C(=O)NCc1cn(nn1)[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O)C(O)=O |r|
Structure:
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