Target
Histone deacetylase 1
Ligand
BDBM50088297
Substrate
n/a
Meas. Tech.
ChEMBL_1476847 (CHEMBL3429770)
IC50
>10000±n/a nM
Citation
 Therrien, ELarouche, GNguyen, NRahil, JLemieux, AMLi, ZFournel, MYan, TPLandry, AJLefebvre, SWang, JJMacBeth, KHeise, CNguyen, ABesterman, JMDéziel, RWahhab, A Discovery of bicyclic pyrazoles as class III histone deacetylase SIRT1 and SIRT2 inhibitors. Bioorg Med Chem Lett 25:2514-8 (2015) [PubMed]  Article
Target
Name:
Histone deacetylase 1
Synonyms:
Cereblon/Histone deacetylase 1 | HD1 | HDAC1 | HDAC1_HUMAN | Histone deacetylase 1 (HDAC1) | Human HDAC1 | RPD3L1
Type:
Enzyme
Mol. Mass.:
55090.27
Organism:
Homo sapiens (Human)
Description:
Q13547
Residue:
482
Sequence:
MAQTQGTRRKVCYYYDGDVGNYYYGQGHPMKPHRIRMTHNLLLNYGLYRKMEIYRPHKANAEEMTKYHSDDYIKFLRSIRPDNMSEYSKQMQRFNVGEDCPVFDGLFEFCQLSTGGSVASAVKLNKQQTDIAVNWAGGLHHAKKSEASGFCYVNDIVLAILELLKYHQRVLYIDIDIHHGDGVEEAFYTTDRVMTVSFHKYGEYFPGTGDLRDIGAGKGKYYAVNYPLRDGIDDESYEAIFKPVMSKVMEMFQPSAVVLQCGSDSLSGDRLGCFNLTIKGHAKCVEFVKSFNLPMLMLGGGGYTIRNVARCWTYETAVALDTEIPNELPYNDYFEYFGPDFKLHISPSNMTNQNTNEYLEKIKQRLFENLRMLPHAPGVQMQAIPEDAIPEESGDEDEDDPDKRISICSSDKRIACEEEFSDSEEEGEGGRKNSSNFKKAKRVKTEDEKEKDPEEKKEVTEEEKTKEEKPEAKGVKEEVKLA
  
Inhibitor
Name:
BDBM50088297
Synonyms:
CHEMBL3427748
Type:
Small organic molecule
Emp. Form.:
C14H13Cl2N3O
Mol. Mass.:
310.179
SMILES:
NC(=O)C1CCCc2c1[nH]nc2-c1ccc(Cl)c(Cl)c1
Structure:
Search PDB for entries with ligand similarity: