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Target
Histone deacetylase 8
Ligand
BDBM50088297
Substrate
n/a
Meas. Tech.
ChEMBL_1476850 (CHEMBL3429773)
IC50
>10000±n/a nM
Citation
 Therrien, E; Larouche, G; Nguyen, N; Rahil, J; Lemieux, AM; Li, Z; Fournel, M; Yan, TP; Landry, AJ; Lefebvre, S; Wang, JJ; MacBeth, K; Heise, C; Nguyen, A; Besterman, JM; Déziel, R; Wahhab, A Discovery of bicyclic pyrazoles as class III histone deacetylase SIRT1 and SIRT2 inhibitors. Bioorg Med Chem Lett 25:2514-8 (2015) [PubMed]  Article
Target
Name:
Histone deacetylase 8
Synonyms:
HD8 | HDAC8 | HDAC8_HUMAN | HDACL1 | Histone deacetylase 8 (HDAC-8) | Human HDAC8
Type:
Enzyme
Mol. Mass.:
41749.60
Organism:
Homo sapiens (Human)
Description:
Q9BY41
Residue:
377
Sequence:
MEEPEEPADSGQSLVPVYIYSPEYVSMCDSLAKIPKRASMVHSLIEAYALHKQMRIVKPKVASMEEMATFHTDAYLQHLQKVSQEGDDDHPDSIEYGLGYDCPATEGIFDYAAAIGGATITAAQCLIDGMCKVAINWSGGWHHAKKDEASGFCYLNDAVLGILRLRRKFERILYVDLDLHHGDGVEDAFSFTSKVMTVSLHKFSPGFFPGTGDVSDVGLGKGRYYSVNVPIQDGIQDEKYYQICESVLKEVYQAFNPKAVVLQLGADTIAGDPMCSFNMTPVGIGKCLKYILQWQLATLILGGGGYNLANTARCWTYLTGVILGKTLSSEIPDHEFFTAYGPDYVLEITPSCRPDRNEPHRIQQILNYIKGNLKHVV
  
Inhibitor
Name:
BDBM50088297
Synonyms:
CHEMBL3427748
Type:
Small organic molecule
Emp. Form.:
C14H13Cl2N3O
Mol. Mass.:
310.179
SMILES:
NC(=O)C1CCCc2c1[nH]nc2-c1ccc(Cl)c(Cl)c1
Structure:
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