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Target
Serine/threonine-protein kinase Chk1
Ligand
BDBM50091283
Substrate
n/a
Meas. Tech.
ChEMBL_1500168 (CHEMBL3584717)
IC50
5.1±n/a nM
Citation
 Gazzard, L; Williams, K; Chen, H; Axford, L; Blackwood, E; Burton, B; Chapman, K; Crackett, P; Drobnick, J; Ellwood, C; Epler, J; Flagella, M; Gancia, E; Gill, M; Goodacre, S; Halladay, J; Hewitt, J; Hunt, H; Kintz, S; Lyssikatos, J; Macleod, C; Major, S; Médard, G; Narukulla, R; Ramiscal, J; Schmidt, S; Seward, E; Wiesmann, C; Wu, P; Yee, S; Yen, I; Malek, S Mitigation of Acetylcholine Esterase Activity in the 1,7-Diazacarbazole Series of Inhibitors of Checkpoint Kinase 1. J Med Chem 58:5053-74 (2015) [PubMed]  Article
Target
Name:
Serine/threonine-protein kinase Chk1
Synonyms:
CHEK1 | CHK1 | CHK1 checkpoint homolog | CHK1_HUMAN | Checkpoint kinase-1 (CHK1)
Type:
Enzyme Catalytic Domain
Mol. Mass.:
54443.02
Organism:
Homo sapiens (Human)
Description:
gi_166295192
Residue:
476
Sequence:
MAVPFVEDWDLVQTLGEGAYGEVQLAVNRVTEEAVAVKIVDMKRAVDCPENIKKEICINKMLNHENVVKFYGHRREGNIQYLFLEYCSGGELFDRIEPDIGMPEPDAQRFFHQLMAGVVYLHGIGITHRDIKPENLLLDERDNLKISDFGLATVFRYNNRERLLNKMCGTLPYVAPELLKRREFHAEPVDVWSCGIVLTAMLAGELPWDQPSDSCQEYSDWKEKKTYLNPWKKIDSAPLALLHKILVENPSARITIPDIKKDRWYNKPLKKGAKRPRVTSGGVSESPSGFSKHIQSNLDFSPVNSASSEENVKYSSSQPEPRTGLSLWDTSPSYIDKLVQGISFSQPTCPDHMLLNSQLLGTPGSSQNPWQRLVKRMTRFFTKLDADKSYQCLKETCEKLGYQWKKSCMNQVTISTTDRRNNKLIFKVNLLEMDDKILVDFRLSKGDGLEFKRHFLKIKGKLIDIVSSQKIWLPAT
  
Inhibitor
Name:
BDBM50091283
Synonyms:
CHEMBL3582232
Type:
Small organic molecule
Emp. Form.:
C26H24N6
Mol. Mass.:
420.509
SMILES:
C(N1CCCCC1)c1ccc(cc1)-c1cnc2[nH]c3cnc(cc3c2c1)-c1cncnc1
Structure:
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