Reaction Details  Report a problem with these data
Target
5-hydroxytryptamine receptor 7
Ligand
BDBM50094273
Substrate
n/a
Meas. Tech.
ChEMBL_1503762 (CHEMBL3592643)
Ki
379±n/a nM
Citation
 Czopek, A; Kolaczkowski, M; Bucki, A; Byrtus, H; Pawlowski, M; Kazek, G; Bojarski, AJ; Piaskowska, A; Kalinowska-Tluscik, J; Partyka, A; Wesolowska, A Novel spirohydantoin derivative as a potent multireceptor-active antipsychotic and antidepressant agent. Bioorg Med Chem 23:3436-47 (2015) [PubMed]  Article
Target
Name:
5-hydroxytryptamine receptor 7
Synonyms:
5-HT-7 | 5-HT-X | 5-HT7 | 5-HT7L | 5-HT7S | 5-Hydroxytryptamine receptor 7 (5-HT7) | 5-hydroxytryptamine receptor 7 | 5-hydroxytryptamine receptor 7 (5-HT-7) | 5HT7R_RAT | Adrenergic Alpha | GPRFO | Htr7 | Serotonin (5-HT) receptor | Serotonin Receptor 7
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
49852.62
Organism:
Rattus norvegicus (rat)
Description:
Rat cloned 5-HT7R.
Residue:
448
Sequence:
MMDVNSSGRPDLYGHLRSLILPEVGRGLQDLSPDGGAHPVVSSWMPHLLSGFLEVTASPAPTWDAPPDNVSGCGEQINYGRVEKVVIGSILTLITLLTIAGNCLVVISVCFVKKLRQPSNYLIVSLALADLSVAVAVMPFVSVTDLIGGKWIFGHFFCNVFIAMDVMCCTASIMTLCVISIDRYLGITRPLTYPVRQNGKCMAKMILSVWLLSASITLPPLFGWAQNVNDDKVCLISQDFGYTIYSTAVAFYIPMSVMLFMYYQIYKAARKSAAKHKFPGFPRVQPESVISLNGVVKLQKEVEECANLSRLLKHERKNISIFKREQKAATTLGIIVGAFTVCWLPFFLLSTARPFICGTSCSCIPLWVERTCLWLGYANSLINPFIYAFFNRDLRTTYRSLLQCQYRNINRKLSAAGMHEALKLAERPERSEFVLQNSDHCGKKGHDT
  
Inhibitor
Name:
BDBM50094273
Synonyms:
CHEMBL3590095
Type:
Small organic molecule
Emp. Form.:
C29H35F3N4O2
Mol. Mass.:
528.609
SMILES:
FC(F)(F)c1cccc(c1)N1CCN(CCCCN2C(=O)NC3(CCC(CC3)c3ccccc3)C2=O)CC1 |(13.77,-9.92,;12.77,-9.21,;12.88,-7.98,;13.89,-8.69,;11.37,-9.85,;11.23,-11.39,;9.83,-12.03,;8.57,-11.14,;8.71,-9.61,;10.11,-8.96,;7.46,-8.72,;6.06,-9.36,;4.8,-8.47,;4.94,-6.94,;3.69,-6.04,;3.84,-4.51,;2.58,-3.61,;2.73,-2.08,;1.47,-1.19,;.02,-1.68,;-.35,-2.86,;-.88,-.44,;.02,.8,;1.44,1.44,;1.61,2.97,;.33,3.9,;-1.05,3.27,;-1.21,1.7,;.48,5.44,;-.76,6.34,;-.6,7.88,;.81,8.5,;2.05,7.59,;1.89,6.06,;1.47,.33,;2.47,1.05,;6.34,-6.29,;7.6,-7.18,)|
Structure:
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