Reaction Details  Report a problem with these data
Target
Trace amine-associated receptor 1
Ligand
BDBM50359505
Substrate
n/a
Meas. Tech.
ChEMBL_1499376 (CHEMBL3583705)
EC50
189±n/a nM
Citation
 Chiellini, G; Nesi, G; Digiacomo, M; Malvasi, R; Espinoza, S; Sabatini, M; Frascarelli, S; Laurino, A; Cichero, E; Macchia, M; Gainetdinov, RR; Fossa, P; Raimondi, L; Zucchi, R; Rapposelli, S Design, Synthesis, and Evaluation of Thyronamine Analogues as Novel Potent Mouse Trace Amine Associated Receptor 1 (mTAAR1) Agonists. J Med Chem 58:5096-107 (2015) [PubMed]  Article
Target
Name:
Trace amine-associated receptor 1
Synonyms:
TAAR1_MOUSE | Ta1 | Taar1 | Tar1 | Trace amine receptor 1 (TARR1) | Trace amine-associated receptor 1 (TAAR1) | Trace amine-associated receptor1 | Trar1
Type:
Protein
Mol. Mass.:
37635.41
Organism:
Mus musculus (Mouse)
Description:
Q923Y8
Residue:
332
Sequence:
MHLCHAITNISHRNSDWSREVQASLYSLMSLIILATLVGNLIVIISISHFKQLHTPTNWLLHSMAIVDFLLGCLIMPCSMVRTVERCWYFGEILCKVHTSTDIMLSSASIFHLAFISIDRYCAVCDPLRYKAKINISTILVMILVSWSLPAVYAFGMIFLELNLKGVEELYRSQVSDLGGCSPFFSKVSGVLAFMTSFYIPGSVMLFVYYRIYFIAKGQARSINRTNVQVGLEGKSQAPQSKETKAAKTLGIMVGVFLVCWCPFFLCTVLDPFLGYVIPPSLNDALYWFGYLNSALNPMVYAFFYPWFRRALKMVLLGKIFQKDSSRSKLFL
  
Inhibitor
Name:
BDBM50359505
Synonyms:
CHEMBL1182312
Type:
Small organic molecule
Emp. Form.:
C14H14INO2
Mol. Mass.:
355.1709
SMILES:
NCCc1ccc(Oc2ccc(O)cc2)c(I)c1
Structure:
Search PDB for entries with ligand similarity: