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Target
Aurora kinase B
Ligand
BDBM50097414
Substrate
n/a
Meas. Tech.
ChEMBL_1502091 (CHEMBL3586966)
IC50
>10000±n/a nM
Citation
 Sells, TB; Chau, R; Ecsedy, JA; Gershman, RE; Hoar, K; Huck, J; Janowick, DA; Kadambi, VJ; LeRoy, PJ; Stirling, M; Stroud, SG; Vos, TJ; Weatherhead, GS; Wysong, DR; Zhang, M; Balani, SK; Bolen, JB; Manfredi, MG; Claiborne, CF MLN8054 and Alisertib (MLN8237): Discovery of Selective Oral Aurora A Inhibitors. ACS Med Chem Lett 6:630-4 (2015) [PubMed]  Article
Target
Name:
Aurora kinase B
Synonyms:
AIK2 | AIM-1 | AIM1 | AIRK2 | ARK2 | AURKB | AURKB_HUMAN | Aurora B kinase (aurB) | Aurora B-INCENP | Aurora kinase 2 | Aurora kinase B (AURKB) | Aurora-related kinase 2 | STK-1 | STK1 | STK12 | STK5 | Serine/threonine-protein kinase aurora B
Type:
Protein
Mol. Mass.:
39327.72
Organism:
Homo sapiens (Human)
Description:
Q96GD4
Residue:
344
Sequence:
MAQKENSYPWPYGRQTAPSGLSTLPQRVLRKEPVTPSALVLMSRSNVQPTAAPGQKVMENSSGTPDILTRHFTIDDFEIGRPLGKGKFGNVYLAREKKSHFIVALKVLFKSQIEKEGVEHQLRREIEIQAHLHHPNILRLYNYFYDRRRIYLILEYAPRGELYKELQKSCTFDEQRTATIMEELADALMYCHGKKVIHRDIKPENLLLGLKGELKIADFGWSVHAPSLRRKTMCGTLDYLPPEMIEGRMHNEKVDLWCIGVLCYELLVGNPPFESASHNETYRRIVKVDLKFPASVPMGAQDLISKLLRHNPSERLPLAQVSAHPWVRANSRRVLPPSALQSVA
  
Inhibitor
Name:
BDBM50097414
Synonyms:
CHEMBL3586468
Type:
Small organic molecule
Emp. Form.:
C25H16ClFN4O2
Mol. Mass.:
458.872
SMILES:
OC(=O)c1ccc(Nc2ncc3CN=C(c4ccccc4F)c4cc(Cl)ccc4-c3n2)cc1 |t:13|
Structure:
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