Reaction Details  Report a problem with these data
Target
Solute carrier family 22 member 8
Ligand
BDBM50103524
Substrate
n/a
Meas. Tech.
ChEMBL_1482571 (CHEMBL3537392)
IC50
35700±n/a nM
Citation
 Wolman, AT; Gionfriddo, MR; Heindel, GA; Mukhija, P; Witkowski, S; Bommareddy, A; Vanwert, AL Organic anion transporter 3 interacts selectively with lipophilicß-lactam antibiotics. Drug Metab Dispos 41:791-800 (2013) [PubMed]  Article
Target
Name:
Solute carrier family 22 member 8
Synonyms:
Oat3 | Oat3 | Organic anion transporter 3 | Reduced in osteosclerosis transporter | Roct | S22A8_MOUSE | Slc22a8 | Solute carrier family 22 member 8 | mOat3
Type:
PROTEIN
Mol. Mass.:
59254.18
Organism:
Mus musculus
Description:
ChEMBL_104613
Residue:
537
Sequence:
MTFSEILDRVGSMGPFQYLHVTLLALPILGIANHNLLQIFTATTPDHHCRPPPNASLEPWVLPLGPNGKPEKCLRFVHLPNASLPNDTQGATEPCLDGWIYNSTRDTIVTEWDLVCGSNKLKEMAQSVFMAGILVGGPVFGELSDRFGRKPILTWSYLLLAASGSSAAFSPSLTVYMIFRFLCGCSISGISLSTIILNVEWVPTSTRAISSTTIGYCYTIGQFILPGLAYAVPQWRWLQLSVSAAFFIFSLLSWWVPESIRWLVLSGKFSKALKTLQRVATFNGKKEEGEKLTVEELKFNLQKDITSAKVKYGLSDLFRVSILRRVTFCLSLAWFATGFAYYSLAMGVEEFGVNIYILQIIFGGVDIPAKFITILSISYLGRRITQGFLLILAGVAILALIFVSSEMQLLRTALAVFGKGCLSGSFSCLFLYTSELYPTVLRQTGMGISNIWARVGSMIAPLVKITGELQPFIPNVIFGTMTLLGGSAAFFLLETLNRPLPETIEDIQDWYQQTKKTKQEPEAEKASQTIPLKTGGP
  
Inhibitor
Name:
BDBM50103524
Synonyms:
Ceftiofur
Type:
Small organic molecule
Emp. Form.:
C19H17N5O7S3
Mol. Mass.:
523.563
SMILES:
[H][C@]12SCC(CSC(=O)c3ccco3)=C(N1C(=O)[C@H]2NC(=O)C(=N/OC)\c1csc(N)n1)C(O)=O |c:14|
Structure:
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