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Target
C-C chemokine receptor type 5
Ligand
BDBM50109932
Substrate
n/a
Meas. Tech.
ChEMBL_1510163 (CHEMBL3606534)
IC50
69000±n/a nM
Citation
 Xu, GG; Zaidi, SA; Zhang, F; Singh, S; Raborg, TJ; Yuan, Y; Zhang, Y Exploration on natural product anibamine side chain modification toward development of novel CCR5 antagonists and potential anti-prostate cancer agents. Bioorg Med Chem Lett 25:3721-5 (2015) [PubMed]  Article
Target
Name:
C-C chemokine receptor type 5
Synonyms:
C-C CKR-5 | C-C chemokine receptor type 5 | CC-CKR-5 | CCR-5 | CCR5 | CCR5/mu opioid receptor complex | CCR5_HUMAN | CD_antigen=CD195 | CHEMR13 | CMKBR5 | HIV-1 fusion coreceptor
Type:
Enzyme
Mol. Mass.:
40540.21
Organism:
Homo sapiens (Human)
Description:
P51681
Residue:
352
Sequence:
MDYQVSSPIYDINYYTSEPCQKINVKQIAARLLPPLYSLVFIFGFVGNMLVILILINCKRLKSMTDIYLLNLAISDLFFLLTVPFWAHYAAAQWDFGNTMCQLLTGLYFIGFFSGIFFIILLTIDRYLAVVHAVFALKARTVTFGVVTSVITWVVAVFASLPGIIFTRSQKEGLHYTCSSHFPYSQYQFWKNFQTLKIVILGLVLPLLVMVICYSGILKTLLRCRNEKKRHRAVRLIFTIMIVYFLFWAPYNIVLLLNTFQEFFGLNNCSSSNRLDQAMQVTETLGMTHCCINPIIYAFVGEKFRNYLLVFFQKHIAKRFCKCCSIFQQEAPERASSVYTRSTGEQEISVGL
  
Inhibitor
Name:
BDBM50109932
Synonyms:
CHEMBL3604309
Type:
Small organic molecule
Emp. Form.:
C28H32ClN3O4
Mol. Mass.:
510.024
SMILES:
[Cl-].COc1ccc(cc1)C(=O)NCc1c2CCC[n+]2c(C)c(CNC(=O)c2ccc(OC)cc2)c1C
Structure:
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