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Target
Flap endonuclease 1
Ligand
BDBM50121747
Substrate
n/a
Meas. Tech.
ChEMBL_1516648 (CHEMBL3620428)
IC50
>100000±n/a nM
Citation
 Chapman, TM; Gillen, KJ; Wallace, C; Lee, MT; Bakrania, P; Khurana, P; Coombs, PJ; Stennett, L; Fox, S; Bureau, EA; Brownlees, J; Melton, DW; Saxty, B Catechols and 3-hydroxypyridones as inhibitors of the DNA repair complex ERCC1-XPF. Bioorg Med Chem Lett 25:4097-103 (2015) [PubMed]  Article
Target
Name:
Flap endonuclease 1
Synonyms:
DNase IV | FEN-1 | FEN1 | FEN1_HUMAN | Flap structure-specific endonuclease 1 | MF1 | Maturation factor 1 | RAD2 | hFEN-1
Type:
PROTEIN
Mol. Mass.:
42602.57
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1517026
Residue:
380
Sequence:
MGIQGLAKLIADVAPSAIRENDIKSYFGRKVAIDASMSIYQFLIAVRQGGDVLQNEEGETTSHLMGMFYRTIRMMENGIKPVYVFDGKPPQLKSGELAKRSERRAEAEKQLQQAQAAGAEQEVEKFTKRLVKVTKQHNDECKHLLSLMGIPYLDAPSEAEASCAALVKAGKVYAAATEDMDCLTFGSPVLMRHLTASEAKKLPIQEFHLSRILQELGLNQEQFVDLCILLGSDYCESIRGIGPKRAVDLIQKHKSIEEIVRRLDPNKYPVPENWLHKEAHQLFLEPEVLDPESVELKWSEPNEEELIKFMCGEKQFSEERIRSGVKRLSKSRQGSTQGRLDDFFKVTGSLSSAKRKEPEPKGSTKKKAKTGAAGKFKRGK
  
Inhibitor
Name:
BDBM50121747
Synonyms:
CHEMBL3617024
Type:
Small organic molecule
Emp. Form.:
C11H7ClFNO2
Mol. Mass.:
239.63
SMILES:
Oc1cc(c[nH]c1=O)-c1ccc(F)c(Cl)c1
Structure:
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